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Case Reports
. 2023 Jul-Aug;37(4):1501-1506.
doi: 10.1111/jvim.16789. Epub 2023 Jun 13.

A novel meningioma with tyrosine-rich crystals in a 6-year-old Great Dane

Kara Majors  1 , Savannah M Rocha  2 , Rebecca Windsor  1 , Ronald B Tjalkens  2 , Julia Engelien  1 , Tawfik Aboellail  3
Affiliations
Case Reports

A novel meningioma with tyrosine-rich crystals in a 6-year-old Great Dane

Kara Majors et al. J Vet Intern Med. 2023 Jul-Aug.

Abstract

A 6-year-old female spayed Great Dane was evaluated for acute onset cluster seizures. Magnetic resonance imaging (MRI) identified a mass in the olfactory bulbs with a large mucoid component caudal to the primary mass. The mass was removed via transfrontal craniotomy and histopathology revealed a tyrosine crystalline-rich, fibrous meningioma with a high mitotic index. Repeat MRI at 6 months showed no detectable tumor regrowth. The dog is clinically normal with no seizures at the time of publication 10 months after surgery. This meningioma subtype is rare in humans. This unique meningioma occurred in a dog of younger age and uncommon breed for intracranial meningioma. Biological progression of this tumor subtype is unknown; however, growth rate might be slow despite the high mitotic index.

Keywords: atypical; brain tumor; crystal; dog; frontal; neoplasia; olfactory.

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Conflict of interest statement

Authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
T1W postcontrast sagittal image (A) showing the fibrous portion of the mass (red arrow) and mucoid component of the mass (yellow arrow). T2W sagittal image (B) showing the fibrous portion of the mass (red arrow), mucoid component of the mass (yellow arrow), and peritumoral edema (white arrow). T1W postcontrast dorsal plane image (C) showing the fibrous portion of the mass (red arrow) and mucoid component of the mass (yellow arrow). T2W dorsal plane image (D) showing the fibrous portion of the mass (red arrow), mucoid component of the mass (yellow arrow), and peritumoral edema (white arrow).
FIGURE 2
FIGURE 2
(A) Photomicrograph of the forebrain mass. The neoplasm is highly cellular and is composed of interlacing bundles of plump spindle cells with mitotic activity (blue arrow), and embedded multifocal tyrosine crystals (red arrows). Scale = 100 μm. (B) Higher magnification of the mass demonstrates multifocal extracellular crystalloid material exhibiting floret‐like arrangement with many 2 to 3 μm petals (P) that surround 30 μm elongated central core (C). Scale = 100 μm.
FIGURE 3
FIGURE 3
Immunofluorescence staining of tyrosine hydroxylase‐rich crystals. Immunofluorescence staining of tyrosine hydroxylase (cyan) and cellular nuclei (DAPI, blue) in tissue with unremarkable brain pathology (A) and within biopsy tissue section of case study patient (B). Scale bars in low magnification montage images = 200 μM and scale bars in high magnification insets = 10 μM.
FIGURE 4
FIGURE 4
Six month postoperative sagittal (A) and dorsal (B) T2‐weighted MRI images.
See this image and copyright information in PMC

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