Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 23;19(3):618-625.
doi: 10.5114/aoms.2019.88595. eCollection 2023.

Subtype of breast cancer influences sentinel lymph node positivity

Piotr Kędzierawski  1   2 , Artur Bocian  3 , Agnieszka Radowicz-Chil  2   4 , Anna Huruk-Kuchinka  1 , Ryszard Mężyk  5
Affiliations

Subtype of breast cancer influences sentinel lymph node positivity

Piotr Kędzierawski et al. Arch Med Sci. .

Abstract

Introduction: The purpose of the study was to determine the correlation between biological subtype of breast cancer and the risk of its metastasis to a sentinel lymph node.

Material and methods: In the analysed group there were 1018 women with breast cancer, clinically node negative, untreated previously. Luminal A subtype was recognised in 57% of patients. A positive sentinel lymph node was detected in 26.5% of women.

Results: In the multivariate analysis only age and tumour size proved to be significant for the entire group, respectively: OR = 0.59, p = 0.0004; OR = 1.96; p < 0.0001. For Luminal A subtype values were OR = 0.51, p = 0.0007; OR = 1.78, p = 0.0045, respectively. For Luminal B patients, in women over 61 years, the risk of sentinel node metastasis probability decreases by 67% and for tumours over 21 mm the probability of positive sentinel node metastasis increases by 117%.

Conclusions: According to our analysis luminal breast cancers are most numerous subtypes, and in these cases we expect more frequent instances of metastasis to a sentinel node. Following the most updated and modern procedures of breast cancer patients' treatment a procedure of sentinel lymph node biopsy is used, replacing an aggressive treatment in the axilla region. In regards to our analysis we should be more vigilant in estimation of regional lymph nodes in luminal patients under sixty with high grade tumours and the tumour diameter more than 20 mm.

Keywords: biological subtype; breast cancer; sentinel lymph node biopsy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A receiver operating characteristic analysis was performed for a sentinel node negative and positive and for independent variables: age, grade and a tumour size
See this image and copyright information in PMC

References

    1. Yoshihara E, Smeets A, Laenen A, et al. . Predictors of axillary lymph node metastases in early breast cancer and their applicability in clinical practice. Breast 2013; 22: 357-61. - PubMed
    1. Holm-Rasmussen EV, Jensen MB, Balslev E, et al. . Reduced risk of axillary lymphatic spread in triple-negative breast cancer. Breast Cancer Res Treat 2015; 149: 229-36. - PubMed
    1. Kędzierawski P, Bocian A, Ciepiela I, Kołacińska A, Macek P, Góźdź S. Treatment outcomes of 213 breast cancer patients after sentinel node biopsy-single center experience. Arch Med Sci Civil Dis 2017; 2: e130-e4.
    1. He ZY, Wu SG, Yang Q, et al. . Breast cancer subtype is associated with axillary lymph node metastasis: a retrospective cohort study. Medicine (Baltimore) 2015; 94: e2213. - PMC - PubMed
    1. Mattes MD, Bhatia JK, Metzger D, Ashamalla H, Katsoulakis E. Breast cancer subtype as a predictor of lymph node metastasis according to the SEER registry. J Breast Cancer 2015; 18: 143-8. - PMC - PubMed