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Review
. 2023 Mar-Apr;55(2):138-140.
doi: 10.4103/ijp.ijp_811_21.

Genital ulcers following all-trans-retinoic acid therapy: A case series with review of literature

Neerja Saraswat  1 , Sushil Kumar  1 , Rahul Prem  2 , Durga Madhab Tripathi  1
Affiliations
Review

Genital ulcers following all-trans-retinoic acid therapy: A case series with review of literature

Neerja Saraswat et al. Indian J Pharmacol. 2023 Mar-Apr.

Abstract

All-trans-retinoic acid (ATRA) has transformed the treatment of acute promyelocytic leukemia. Most of the adverse effects associated with this drug are minor barring differentiation syndromes. Genital ulcers feature among the underreported adverse effects of ATRA which needs to be kept in mind to avoid life-threatening complications. We describe two cases who developed genital ulcers while treated with ATRA.

Keywords: Acute promyelocytic leukemia; all-trans-retinoic acid; genital ulcers.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Dermatological examination revealed six superficial ulcers, two at 3 o’ clock and one each at 7, 9, and 12 o’ clock position
Figure 2
Figure 2
Examination of the ulcer revealed solitary, superficial ulcer with clean base
See this image and copyright information in PMC

References

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