Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;55(9):2145-2154.
doi: 10.1007/s11255-023-03665-3. Epub 2023 Jun 14.

Association between oxidative balance score and urinary incontinence in females: results from the national health and nutrition examination survey in 2005-2018

Ye Yuan #  1 , Wei Tan  1 , Yinchao Huang  1 , Hao Huang  1 , Yadong Li  1 , Yuanqing Gou  1 , Shengjie Zeng  1 , Zili Hu  2
Affiliations

Association between oxidative balance score and urinary incontinence in females: results from the national health and nutrition examination survey in 2005-2018

Ye Yuan et al. Int Urol Nephrol. 2023 Sep.

Abstract

Purpose: Oxidative stress plays a crucial role in the pathogenesis of urinary incontinence (UI). This study aimed to assess the association between the oxidative balance score (OBS) and UI in adult females in the United States.

Methods: The study utilized data from the National Health and Nutrition Examination Survey database, spanning from 2005 to 2018. Weighted multivariate logistic regression, subgroup analyses, and restricted cubic spline regression were conducted to determine the odds ratio (OR) and 95% confidence intervals (95% CI) regarding the association between OBS and UI. Sensitivity analyses were performed to assess the robustness of the findings.

Results: A total of 7304 participants were enrolled in this study. After adjusting for potential confounders, participants with lower OBS were found to have a higher likelihood of experiencing stress, urge, and mixed incontinence (OR, 0.986; 95% CI 0.975-0.998; p = 0.022; OR, 0.978; 95% CI 0.963-0.993; p = 0.004; and OR, 0.975; 95% CI 0.961-0.990; p = 0.001). Lifestyle factors were strongly associated with the prevalence and frequency of UI. The results remained consistent, and no significant interaction effects were observed in the subgroup analyses. The prevalence of three types of UI exhibited a nonlinear inverted U-shaped trend with increasing in OBS and dietary OBS (p for nonlinear < 0.05).

Conclusion: Among females, the higher the OBS, the lower the prevalence of UI. Therefore, dietary and lifestyle-related antioxidant therapy for females with UI should receive attention and be subject to further investigation.

Keywords: Females; National health and nutrition examination survey; Oxidative balance score; Urinary incontinence.

PubMed Disclaimer

References

    1. Rogers R, Pauls R, Thakar R, Morin M, Kuhn A, Petri E et al (2018) An international urogynecological association (IUGA)/international continence society (ICS) joint report on the terminology for the assessment of sexual health of women with pelvic floor dysfunction. Int Urogynecol J 29(5):647–666. https://doi.org/10.1007/s00192-018-3603-9 - DOI - PubMed
    1. Milsom I, Gyhagen M (2019) The prevalence of urinary incontinence. Climacteric 22(3):217–222. https://doi.org/10.1080/13697137.2018.1543263 - DOI - PubMed
    1. Pang H, Lv J, Xu T, Li Z, Gong J, Liu Q et al (2022) Incidence and risk factors of female urinary incontinence: a 4-year longitudinal study among 24 985 adult women in China. BJOG 129(4):580–589. https://doi.org/10.1111/1471-0528.16936 - DOI - PubMed
    1. Zordani A, Pisciotta A, Bertoni L, Bertani G, Vallarola A, Giuliani D et al (2019) Regenerative potential of human dental pulp stem cells in the treatment of stress urinary incontinence: in vitro and in vivo study. Cell Prolif 52(6):e12675. https://doi.org/10.1111/cpr.12675 - DOI - PubMed - PMC
    1. Karnia M, Myslinska D, Dzik K, Flis D, Ciepielewski Z, Podlacha M et al (2018) The electrical stimulation of the bed nucleus of the stria terminalis causes oxidative stress in skeletal muscle of rats. Oxid Med Cell Longev. https://doi.org/10.1155/2018/4671213 - DOI - PubMed - PMC

LinkOut - more resources