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. 2023 Jun 14;18(6):e0286665.
doi: 10.1371/journal.pone.0286665. eCollection 2023.

Seroprevalence of SARS-CoV-2 IgG and associated factors among people living with HIV over the first 12 months following the outbreak of COVID-19 in Burkina Faso, a sub-Saharan African country

Odilon D Kaboré  1   2   3 , Armel Poda  2   3   4 , Cheick Ahmed Ouattara  2   3 , Fernand N Michodigni  2 , Abdoul-Aziz Belem  2 , Yacouba Sawadogo  1   2 , Jacques Zoungrana  3   4 , Lokman Galal  5   6 , Clément Z Meda  3 , Sylvain Godreuil  5   6 , Abdoul-Salam Ouédraogo  1   2   3   7
Affiliations

Seroprevalence of SARS-CoV-2 IgG and associated factors among people living with HIV over the first 12 months following the outbreak of COVID-19 in Burkina Faso, a sub-Saharan African country

Odilon D Kaboré et al. PLoS One. .

Abstract

Objective: This study aimed to evaluate the seroprevalence of anti-SARS-CoV-2 IgG and factors associated with the infection among PLWHIV over the first 12 months following the outbreak of COVID-19 in Burkina Faso.

Design: A retrospective cross-sectional study of plasma samples collected from March 9, 2020, and March 8, 2021, at the outpatient HIV referral center, before the introduction of the SARS-CoV-2 vaccine in Burkina Faso.

Methods: Anti-SARS-CoV-2 IgG were detected in plasma using DS-ЕIA-ANTI-SARS-CoV-2-G (S) kit. Logistic regressions were used to compare SARS-CoV-2 specific immune responses between groups and within subgroups.

Results and discussion: A total of 419 plasma were subjected to serological diagnosis. None of the participants was vaccinated against COVID-19 during the period of sample collection, and 130 samples were positive for anti-SARS-CoV-2 IgG, giving a prevalence of 31.0% (95% CI 26.6-35.7). The median CD4 cell count was 661 cells/μL (IQR,422-928). Retailers had half the risk of being infected compared to housemaids with an OR of 0.49 (p = 0.028, 95% CI 0.26-0.91). Likewise, the risk of infection was 1.69 times higher in patients on integrase inhibitors compared to that of patients on non-nucleoside reverse transcriptase inhibitors (p = 0.020, 95% CI 1.09-2.63).

Conclusion: Our study reveals a high seroprevalence among PLWHIV to SARS-CoV-2 during the first year of the pandemic. In addition, PLWHIV on integrase inhibitors are 1.69 times more likely to be infected than PLWHIV on non-nucleoside inhibitors, and this observation remains an intriguing topic that still needs to be clarified.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Distribution of Sars-Cov-2 Ig G seropositive and seronegative individuals among the 419 PLWHIV enrolled.
Fig 2
Fig 2. Month by month anti SARS-CoV-2 IgG seroprevalence.
See this image and copyright information in PMC

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