SWI/SNF chromatin remodeling complexes as key regulators of CD8⁺ T cell fate

Lisa Rausch¹, Axel Kallies²

Affiliations

¹ The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia.
² The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia. Electronic address: axel.kallies@unimelb.edu.au.

PMID: 37315531
DOI: 10.1016/j.immuni.2023.05.018

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SWI/SNF chromatin remodeling complexes as key regulators of CD8⁺ T cell fate

Lisa Rausch et al. Immunity. 2023.

Free article

. 2023 Jun 13;56(6):1162-1164.

doi: 10.1016/j.immuni.2023.05.018.

Authors

Lisa Rausch¹, Axel Kallies²

Affiliations

¹ The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia.
² The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia. Electronic address: axel.kallies@unimelb.edu.au.

PMID: 37315531
DOI: 10.1016/j.immuni.2023.05.018

Abstract

CD8⁺ T cell fate is tightly regulated by epigenetic modification. In this issue of Immunity, McDonald et al. and Baxter et al. demonstrate that the chromatin remodeling complexes cBAF and PBAF control proliferation, differentiation, and function of cytotoxic T cells in response to infection as well as cancer.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8⁺ T cells.
Baxter AE, Huang H, Giles JR, Chen Z, Wu JE, Drury S, Dalton K, Park SL, Torres L, Simone BW, Klapholz M, Ngiow SF, Freilich E, Manne S, Alcalde V, Ekshyyan V, Berger SL, Shi J, Jordan MS, Wherry EJ. Baxter AE, et al. Immunity. 2023 Jun 13;56(6):1320-1340.e10. doi: 10.1016/j.immuni.2023.05.008. Immunity. 2023. PMID: 37315535

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SWI/SNF chromatin remodeling complexes as key regulators of CD8⁺ T cell fate

Affiliations

SWI/SNF chromatin remodeling complexes as key regulators of CD8⁺ T cell fate

Authors

Affiliations

Abstract

Conflict of interest statement

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Research Materials