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Comment
. 2023 Jun 13;56(6):1165-1167.
doi: 10.1016/j.immuni.2023.05.015.

Cancer immunity derailed: PGE2 misconducts cDC1s

Matthew Brown  1 , Michelle A Tran  1 , Nina Bhardwaj  2
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Comment

Cancer immunity derailed: PGE2 misconducts cDC1s

Matthew Brown et al. Immunity. .
Free article

Abstract

Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.

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Conflict of interest statement

Declaration of interests N.B. is an extramural member of the Parker Institute for Cancer Immunotherapy (PICI), receives research funds from Regeneron, Antidote, and Dragonfly Therapeutics, and is on the advisory boards of Novartis, Rome Therapeutics, BreakBio, Carisma Therapeutics, Genotwin, the Cancer Research Institute, and on the Board of Directors for the American Association for Cancer Research (AACR).

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