Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;73(6):847-853.
doi: 10.1016/j.identj.2023.05.002. Epub 2023 Jun 12.

Mendelian Randomisation Study on Association of Gut Microbiota and Periodontitis

Jukun Song  1 , Yadong Wu  1 , Xinhai Yin  2 , Hong Ma  1 , Junmei Zhang  3
Affiliations

Mendelian Randomisation Study on Association of Gut Microbiota and Periodontitis

Jukun Song et al. Int Dent J. 2023 Dec.

Abstract

Objective: Several studies have demonstrated the possible association between gut microbiota and periodontitis. The mechanism by which gut microbiota contribute to periodontitis remains unknown.

Methods: A 2-sample Mendelian randomisation (MR) study was conducted using publicly available Genome-Wide Association Studies (GWAS) data of European ancestry. The relationships between gut microbiota and tooth loss and periodontitis were assessed using summary-level data. Moreover, inverse variance weighted (IVW), MR-Egger, weighted median, and simple Mendelian were used. The results were further validated using sensitivity analyses.

Results: A total of 211 gut microbiota were studied, including 9 phyla, 16 classes, 20 orders, 35 families, and 131 genera. The IVW method identified 16 bacterial genera related to the risk of periodontitis and tooth loss. Lactobacillaceae was associated with an increased risk of periodontitis (odds ratio [OR], 1.40, 95% confidence interval [CI], 1.03-1.91, P<.001) and tooth loss (OR, 1.12; 95% CIs, 1.02-1.24, P = .002), whereas Lachnospiraceae UCG008 was linked to a lower risk of tooth loss (P = .041). There was no heterogeneity and horizontal pleiotropy in the sensitivity analysis.

Conclusions: Several microorganisms were identified to be linked to the risk of periodontitis. Furthermore, the findings improved our understanding of gut microbiota and periodontitis pathology.

Keywords: Causal relationship; Gut microbiota; Mendelian randomisation; Periodontitis.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest None disclosed.

Figures

Fig 1
Fig. 1
The study design of the present Mendelian randomisation analyses.
Fig 2
Fig. 2
The effect of gut microbial genera on tooth loss and periodontitis identified at the nominal significance (P < .05).
Fig 3
Fig. 3
Forest plot of the links between genetically determined 6 gut microbial genera with the risks of tooth loss and periodontitis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Michaud DS, Fu Z, Shi J, Chung M. Periodontal disease, tooth loss, and cancer risk. Epidemiol Rev. 2017;39(1):49–58. - PMC - PubMed
    1. Deng K, Pelekos G, Jin L, Tonetti MS. Gingival bleeding on brushing as a sentinel sign of gingival inflammation: a diagnostic accuracy trial for the discrimination of periodontal health and disease. J Clin Periodontol. 2021;48(12):1537–1548. - PMC - PubMed
    1. Eke PI, Dye BA, Wei L, et al. Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012. J Periodontol. 2015;86(5):611–622. - PMC - PubMed
    1. Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038. - PubMed
    1. Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021;21(7):426–440. - PMC - PubMed