Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov;23(11):749-762.
doi: 10.1038/s41577-023-00890-w. Epub 2023 Jun 14.

Regulatory T cells in the face of the intestinal microbiota

Deepshika Ramanan  1 , Alvin Pratama  1 , Yangyang Zhu  1 , Olivia Venezia  1 , Martina Sassone-Corsi  1 , Kaitavjeet Chowdhary  1 , Silvia Galván-Peña  1 , Esen Sefik  2 , Chrysothemis Brown  3   4   5 , Adélaïde Gélineau  1 , Diane Mathis  1 , Christophe Benoist  6
Affiliations
Review

Regulatory T cells in the face of the intestinal microbiota

Deepshika Ramanan et al. Nat Rev Immunol. 2023 Nov.

Abstract

Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders. Startling new information has appeared in recent years on their diversity, the importance of the transcription factor FOXP3, how T cell receptors influence their fate and the unexpected and varied cellular partners that influence Treg cell homeostatic setpoints. We also revisit some tenets, maintained by the echo chambers of Reviews, that rest on uncertain foundations or are a subject of debate.

PubMed Disclaimer

References

    1. Tanoue, T., Atarashi, K. & Honda, K. Development and maintenance of intestinal regulatory T cells. Nat. Rev. Immunol. 16, 295–309 (2016). - PubMed - DOI
    1. Russler-Germain, E. V., Rengarajan, S. & Hsieh, C. S. Antigen-specific regulatory T-cell responses to intestinal microbiota. Mucosal Immunol. 10, 1375–1386 (2017). - PubMed - PMC - DOI
    1. Jacobse, J. et al. Intestinal regulatory T cells as specialized tissue-restricted immune cells in intestinal immune homeostasis and disease. Front. Immunol. 12, 716499 (2021). - PubMed - PMC - DOI
    1. Traxinger, B. R., Richert-Spuhler, L. E. & Lund, J. M. Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry. Mucosal Immunol. 15, 398–407 (2022). - PubMed - DOI
    1. van der Veeken, J. et al. The transcription factor Foxp3 shapes regulatory T cell identity by tuning the activity of trans-acting intermediaries. Immunity 53, 971–984 (2020). - PubMed - PMC - DOI

LinkOut - more resources