Refractory somatotroph adenomas

doi:10.1007/s11102-023-01324-5

Review

. 2023 Jun;26(3):266-268.

doi: 10.1007/s11102-023-01324-5. Epub 2023 Jun 15.

Refractory somatotroph adenomas

Monica R Gadelha^{1

2

3

4}, Leandro Kasuki^{5

6}

Affiliations

¹ Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital, Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. mgadelha@hucff.ufrj.br.
² Neuroendocrine Unit, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil. mgadelha@hucff.ufrj.br.
³ Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil. mgadelha@hucff.ufrj.br.
⁴ , Rua Prof. Rodolpho Paulo Rocco, 255, 9th floor, Ilha do Fundão, Rio de Janeiro, 21941-913, Brazil. mgadelha@hucff.ufrj.br.
⁵ Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital, Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
⁶ Neuroendocrine Unit, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil.

PMID: 37316636
DOI: 10.1007/s11102-023-01324-5

Review

Refractory somatotroph adenomas

Monica R Gadelha et al. Pituitary. 2023 Jun.

. 2023 Jun;26(3):266-268.

doi: 10.1007/s11102-023-01324-5. Epub 2023 Jun 15.

Authors

Monica R Gadelha^{1

2

3

4}, Leandro Kasuki^{5

6}

Affiliations

¹ Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital, Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. mgadelha@hucff.ufrj.br.
² Neuroendocrine Unit, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil. mgadelha@hucff.ufrj.br.
³ Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil. mgadelha@hucff.ufrj.br.
⁴ , Rua Prof. Rodolpho Paulo Rocco, 255, 9th floor, Ilha do Fundão, Rio de Janeiro, 21941-913, Brazil. mgadelha@hucff.ufrj.br.
⁵ Endocrine Unit and Neuroendocrinology Research Center, Medical School and Hospital, Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
⁶ Neuroendocrine Unit, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, Brazil.

PMID: 37316636
DOI: 10.1007/s11102-023-01324-5

Abstract

Somatotroph adenomas are usually controlled with standard therapy, which can include surgery, medical treatment and radiotherapy. Some tumors have a more aggressive behavior and are refractory to standard therapy. In this review, we summarize the phenotype of these tumors and the current options for their management.

Keywords: Acromegaly; Aggressive adenomas; Pasireotide; Pegvisomant; Somatostatin receptor ligands.

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References

1. Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V, Trouillas J, Dekkers OM, Endocrinology E, S.o (2018) European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas. Eur J Endocrinol 178:G1–G24 - DOI - PubMed
1. Liu X, Dai C, Feng M, Li M, Chen G, Wang R (2021) Diagnosis and treatment of refractory pituitary adenomas: a narrative review. Gland Surg 10:1499–1507 - DOI - PubMed - PMC
1. Conficoni A, Feraco P, Mazzatenta D, Zoli M, Asioli S, Zenesini C, Fabbri VP, Cellerini M, Bacci A (2020) Biomarkers of pituitary macroadenomas aggressive behaviour: a conventional MRI and DWI 3T study. Br J Radiol 93:20200321 - DOI - PubMed - PMC
1. Antunes X, Ventura N, Camilo GB, Wildemberg LE, Guasti A, Pereira PJM, Camacho AHS, Chimelli L, Niemeyer P, Gadelha MR, Kasuki L (2018) Predictors of surgical outcome and early criteria of remission in acromegaly. Endocrine 60:415–422 - DOI - PubMed
1. Gadelha MR, Kasuki L, Korbonits M (2013) Novel pathway for somatostatin analogs in patients with acromegaly. Trends Endocrinol Metab 24:238–246 - DOI - PubMed

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[1] Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V, Trouillas J, Dekkers OM, Endocrinology E, S.o (2018) European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas. Eur J Endocrinol 178:G1–G24 - DOI - PubMed

[2] Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V, Trouillas J, Dekkers OM, Endocrinology E, S.o (2018) European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas. Eur J Endocrinol 178:G1–G24 - DOI - PubMed

[3] Liu X, Dai C, Feng M, Li M, Chen G, Wang R (2021) Diagnosis and treatment of refractory pituitary adenomas: a narrative review. Gland Surg 10:1499–1507 - DOI - PubMed - PMC

[4] Liu X, Dai C, Feng M, Li M, Chen G, Wang R (2021) Diagnosis and treatment of refractory pituitary adenomas: a narrative review. Gland Surg 10:1499–1507 - DOI - PubMed - PMC

[5] Conficoni A, Feraco P, Mazzatenta D, Zoli M, Asioli S, Zenesini C, Fabbri VP, Cellerini M, Bacci A (2020) Biomarkers of pituitary macroadenomas aggressive behaviour: a conventional MRI and DWI 3T study. Br J Radiol 93:20200321 - DOI - PubMed - PMC

[6] Conficoni A, Feraco P, Mazzatenta D, Zoli M, Asioli S, Zenesini C, Fabbri VP, Cellerini M, Bacci A (2020) Biomarkers of pituitary macroadenomas aggressive behaviour: a conventional MRI and DWI 3T study. Br J Radiol 93:20200321 - DOI - PubMed - PMC

[7] Antunes X, Ventura N, Camilo GB, Wildemberg LE, Guasti A, Pereira PJM, Camacho AHS, Chimelli L, Niemeyer P, Gadelha MR, Kasuki L (2018) Predictors of surgical outcome and early criteria of remission in acromegaly. Endocrine 60:415–422 - DOI - PubMed

[8] Antunes X, Ventura N, Camilo GB, Wildemberg LE, Guasti A, Pereira PJM, Camacho AHS, Chimelli L, Niemeyer P, Gadelha MR, Kasuki L (2018) Predictors of surgical outcome and early criteria of remission in acromegaly. Endocrine 60:415–422 - DOI - PubMed

[9] Gadelha MR, Kasuki L, Korbonits M (2013) Novel pathway for somatostatin analogs in patients with acromegaly. Trends Endocrinol Metab 24:238–246 - DOI - PubMed

[10] Gadelha MR, Kasuki L, Korbonits M (2013) Novel pathway for somatostatin analogs in patients with acromegaly. Trends Endocrinol Metab 24:238–246 - DOI - PubMed

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Refractory somatotroph adenomas

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