Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul;31(7):1942-1952.
doi: 10.1002/oby.23784. Epub 2023 Jun 15.

Risk factors for obesity in adulthood among survivors of childhood cancer

Laurène Delacourt  1 , Rodrigue Allodji  2   3   4 , Juliette Chappat  2   3   4 , Nadia Haddy  2   3   4 , Chiraz El-Fayech  5 , Charlotte Demoor-Goldschmidt  2   6   7   8 , Neige Journy  2   3   4 , Stéphanie Bolle  9 , Cécile Thomas-Teinturier  3   10 , Monia Zidane  2   3   4 , Carole Rubino  2   3   4 , Cristina Veres  2   3   4 , Giao Vu-Bezin  2   3   4 , Delphine Berchery  11 , Claire Pluchart  12 , Pierre-Yves Bondiau  13 , Agnès Dumas  3   14 , Nicolas Bougas  14 , Jacques Grill  5   15 , Christelle Dufour  5 , Brice Fresneau  3   4   5 , Hélène Pacquement  1 , Ibrahima Diallo  2   16 , François Doz  1   14 , Florent de Vathaire  2   3   4
Affiliations

Risk factors for obesity in adulthood among survivors of childhood cancer

Laurène Delacourt et al. Obesity (Silver Spring). 2023 Jul.

Abstract

Objective: The aim of this study was to identify risk factors for obesity in childhood cancer survivors (CCSs).

Methods: The study included 3199 patients of the French Childhood Cancer Survivor Study cohort, with 303 patients with obesity who had returned the self-questionnaire. Analyses were adjusted for social deprivation index and sex.

Results: CCSs were less likely to have obesity (9.5%; 95% CI: 8.5%-10.5%) than expected from the general French population rates (12.5%; p = 0.0001). Nevertheless, brain tumor survivors were significantly more likely to develop obesity than the general French population (p = 0.0001). Compared with patients who did not receive radiotherapy to the pituitary gland, those who received a dose >5 Gy had an increased risk of obesity: relative risk 1.9 (95% CI: 1.2-3.1), 2.5 (95% CI: 1.7-3.7), and 2.6 (95% CI: 1.6-4.3), respectively, for participants with 6 to 20 Gy, 20 to 40 Gy, and ≥40 Gy of radiation. Etoposide administration significantly increased the risk of obesity (relative risk 1.7; 95% CI: 1.1-2.6). High social deprivation index was also a risk factor, just like BMI at diagnosis.

Conclusions: Long-term follow-up of CCSs should include weight follow-up during adulthood.

PubMed Disclaimer

References

REFERENCES

    1. Panorama des cancers en France, Edition 2021. Institut National du Cancer; 2021.
    1. Berger C, El Fayech C, Pacquement H, et al. Objectives and organization for the long-term follow-up after childhood cancer. Article in French. Bull Cancer. 2015;102(7-8):579-585.
    1. Sante publique France. Les résultats de l'étude ESTEBAN 2014-2015. Published June 26, 2019. https://www.santepubliquefrance.fr/determinants-de-sante/nutrition-et-ac...
    1. Browne EK, Zhou Y, Chemaitilly W, et al. Changes in body mass index, height, and weight in children during and after therapy for acute lymphoblastic leukemia. Cancer. 2018;124(21):4248-4259.
    1. Belle FN, Weiss A, Schindler M, et al. Overweight in childhood cancer survivors: the Swiss Childhood Cancer Survivor Study. Am J Clin Nutr. 2018;107(1):3-11.

Publication types

LinkOut - more resources