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. 2023 Jun;28(24):2300289.
doi: 10.2807/1560-7917.ES.2023.28.24.2300289.

Fulminant echovirus 11 hepatitis in male non-identical twins in northern Italy, April 2023

Antonio Piralla  1   2 , Alessandro Borghesi  3   2 , Amelia Di Comite  3 , Federica Giardina  4 , Guglielmo Ferrari  1 , Simona Zanette  3 , Tiziana Angelica Figar  3 , Micol Angelini  3 , Camilla Pisoni  3 , Antonino Maria Guglielmo Pitrolo  1 , Stefania Paolucci  1 , Francesca Rovida  1   4 , Isabella Pellicioli  5 , Ezio Bonanomi  5 , Fausto Baldanti  1   4   6 , Stefano Ghirardello  3   6
Affiliations

Fulminant echovirus 11 hepatitis in male non-identical twins in northern Italy, April 2023

Antonio Piralla et al. Euro Surveill. 2023 Jun.

Abstract

Echovirus 11 (E11) has recently been associated with a series of nine neonatal cases of severe hepatitis in France. Here, we present severe hepatitis caused by E11 in a pair of twins. In one of the neonates, the clinical picture evolved to fulminant hepatitis. The E11 genome showed 99% nucleotide identity with E11 strains reported in the cases in France. Rapid genome characterisation using next generation sequencing is essential to identify new and more pathogenetic variants.

Keywords: echovirus 11 (E11); enteroviruses; hepatitis; neonatal infection.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Phylogenetic tree of echovirus 11 complete genome sequences (n = 112)
See this image and copyright information in PMC

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