Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan-Dec:29:10760296231180170.
doi: 10.1177/10760296231180170.

Clinical Application of Thromboelastography in Patients With Severe Fever With Thrombocytopenia Syndrome

Yingbo Li  1 , Changjuan An  1 , Peng Xue  1 , Lina Ni  1 , Xia Yu  1 , Jiangli Qu  1 , Yingjie Yao  1 , Chengyong Yu  1
Affiliations

Clinical Application of Thromboelastography in Patients With Severe Fever With Thrombocytopenia Syndrome

Yingbo Li et al. Clin Appl Thromb Hemost. 2023 Jan-Dec.

Abstract

Aim: To investigate the clinical application of thromboelastography (TEG) in severe fever with thrombocytopenia syndrome (SFTS).

Methods: One hundred and fifty-seven patients with SFTS were included in the study. The participants were distributed into 3 groups; A, B, and C. And 103 patients in group A met the clinical criteria as they exhibited slight liver and kidney dysfunction. Group B consisted of 54 patients with SFTS who were critically ill while group C was a healthy control group with 58 participants.

Results: Patients with SFTS exhibited lower coagulation than the healthy participants. Group B patients exhibited significantly lower coagulation compared to group A. There was no significant difference in platelet count and fibrinogen content between patients in group A and group B, but platelet aggregation function and fibrinogen activity were significantly lower in group B patients.

Conclusion: Our results suggest that it is risky to solely rely on platelet count and the fibrinogen in SFTS. Monitoring of TEG and other coagulation indexes should be emphasized.

Keywords: SFTS; fibrinogen; platelet aggregation; thromboelastography.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Similar articles

See all similar articles

References

    1. Yu XJ, Liang MF, Zhang SY, et al.Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364(16):1523-15325. - PMC - PubMed
    1. Liu K, Zhou H, Sun RX, et al.A national assessment of the epidemiology of severe fever with thrombocytopenia syndrome, China. Sci Rep. 2015;5:9679. - PMC - PubMed
    1. He Z, Wang B, Li Y, et al.Severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis of epidemiology, clinical signs, routine laboratory diagnosis, risk factors, and outcomes. BMC Infect Dis. 2020 Aug 5;20(1):575. - PMC - PubMed
    1. Sun JM, Zhang YJ, Gong ZY, et al.Seroprevalence of severe fever with thrombocytopenia syndrome virus in southeastern China and analysis of risk factors. Epidemiol Infect. 2014;143(4):851-861. - PMC - PubMed
    1. Zhan J, Wang Q, Cheng J, et al.Current status of sever fever with thrombocytopenia syndrome in China. Virol Sin. 2017;32(1):51-62. - PMC - PubMed

LinkOut - more resources