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. 2023 Jan-Dec:29:10760296231180170.
doi: 10.1177/10760296231180170.

Clinical Application of Thromboelastography in Patients With Severe Fever With Thrombocytopenia Syndrome

Yingbo Li  1 , Changjuan An  1 , Peng Xue  1 , Lina Ni  1 , Xia Yu  1 , Jiangli Qu  1 , Yingjie Yao  1 , Chengyong Yu  1
Affiliations

Clinical Application of Thromboelastography in Patients With Severe Fever With Thrombocytopenia Syndrome

Yingbo Li et al. Clin Appl Thromb Hemost. 2023 Jan-Dec.

Abstract

Aim: To investigate the clinical application of thromboelastography (TEG) in severe fever with thrombocytopenia syndrome (SFTS).

Methods: One hundred and fifty-seven patients with SFTS were included in the study. The participants were distributed into 3 groups; A, B, and C. And 103 patients in group A met the clinical criteria as they exhibited slight liver and kidney dysfunction. Group B consisted of 54 patients with SFTS who were critically ill while group C was a healthy control group with 58 participants.

Results: Patients with SFTS exhibited lower coagulation than the healthy participants. Group B patients exhibited significantly lower coagulation compared to group A. There was no significant difference in platelet count and fibrinogen content between patients in group A and group B, but platelet aggregation function and fibrinogen activity were significantly lower in group B patients.

Conclusion: Our results suggest that it is risky to solely rely on platelet count and the fibrinogen in SFTS. Monitoring of TEG and other coagulation indexes should be emphasized.

Keywords: SFTS; fibrinogen; platelet aggregation; thromboelastography.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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