The serotonin theory of depression

Affiliations

¹ Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, 40202, USA. rselma01@louisville.edu.
² Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, 40202, USA.

Comment

Rif S El-Mallakh et al. Mol Psychiatry. 2023 Aug.

. 2023 Aug;28(8):3157.

doi: 10.1038/s41380-023-02091-2. Epub 2023 Jun 16.

¹ Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, 40202, USA. rselma01@louisville.edu.
² Mood Disorders Research Program, Depression Center, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, 40202, USA.

No abstract available

Comment on

The serotonin theory of depression: a systematic umbrella review of the evidence.
Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. Moncrieff J, et al. Mol Psychiatry. 2023 Aug;28(8):3243-3256. doi: 10.1038/s41380-022-01661-0. Epub 2022 Jul 20. Mol Psychiatry. 2023. PMID: 35854107 Free PMC article.

1. Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2022:1–14. https://doi.org/10.1038/s41380-022-01661-0 .
1. Robinson J. The serotonin theory of depression: how the media got it all wrong. Pharmaceutical J. 2022. https://pharmaceutical-journal.com/article/feature/the-serotonin-theory-... . Accessed 6 October 2022.
1. Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391:1357–66. https://doi.org/10.1016/S0140-6736(17)32802-7 . - DOI - PubMed - PMC
1. Meyniel F, Goodwin GM, Deakin JW, Klinge C, MacFadyen C, Milligan H, et al. A specific role for serotonin in overcoming effort cost. Elife. 2016;5:e17282. https://doi.org/10.7554/eLife.17282 . - DOI - PubMed - PMC
1. El-Mallakh RS, Gao Y, Jeannie Roberts R. Tardive dysphoria: the role of long term antidepressant use in-inducing chronic depression. Med Hypotheses. 2011;76:769–73. https://doi.org/10.1016/j.mehy.2011.01.020 . - DOI - PubMed