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. 2023 Jun 15;190(7):261.
doi: 10.1007/s00604-023-05839-3.

A molecularly imprinted electrochemical sensor with dual functional monomers for selective determination of gatifloxacin

Yan Huang  1 , Xuyuan Sun  1 , Jing Yang  1 , Zhiyuan Cao  1 , Rujie Wang  1 , Li Li  2 , Yaping Ding  3   4
Affiliations

A molecularly imprinted electrochemical sensor with dual functional monomers for selective determination of gatifloxacin

Yan Huang et al. Mikrochim Acta. .

Abstract

A molecularly imprinted electrochemical sensor was designed for the selective determination of gatifloxacin (GTX) based on dual functional monomers. Multi-walled carbon nanotube (MWCNT) enhanced the current intensity and zeolitic imidazolate framework 8 (ZIF8) provided a large surface area to produce more imprinted cavities. In the electropolymerization of molecularly imprinted polymer (MIP), p-aminobenzoic acid (p-ABA) and nicotinamide (NA) were used as dual functional monomers, and GTX was the template molecule. Taking [Fe(CN)6]3-/4- as an electrochemical probe, an oxidation peak on the glassy carbon electrode was located at about 0.16 V (vs. saturated calomel electrode). Due to the diverse interactions among p-ABA, NA, and GTX, the MIP-dual sensor exhibited higher specificity towards GTX than MIP-p-ABA and MIP-NA sensors. The sensor had a wide linear range from 1.00 × 10-14 to 1.00 × 10-7 M with a low detection limit of 2.61 × 10-15 M. Satisfactory recovery between 96.5 and 105% with relative standard deviation from 2.4 to 3.7% in real water samples evidenced the potential of the method in antibiotic contaminant determination.

Keywords: Differential pulse voltammetry; Dual functional monomers; Electrochemical sensor; Gatifloxacin; Molecularly imprinted polymer.

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