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Review
. 2023 Jun;71(6):2379-2384.
doi: 10.4103/ijo.IJO_1784_22.

Enzymatic and biochemical properties of lens in age-related cataract versus diabetic cataract: A narrative review

Deepak Mishra  1 , Anurag Kashyap  1 , Tanmay Srivastav  2 , Archana Yadav  1 , Swasti Pandey  1 , Madan Mohan Majhi  3 , Kirti Verma  1 , A Prabu  4 , Vibha Singh  1
Affiliations
Review

Enzymatic and biochemical properties of lens in age-related cataract versus diabetic cataract: A narrative review

Deepak Mishra et al. Indian J Ophthalmol. 2023 Jun.

Abstract

Cataract is the leading cause of blindness worldwide. There is an increased incidence of cataract formation in the diabetic population due to several factors. Diabetes mellitus accelerates the development of cataract. Oxidative stress results in most of the diabetic complications including diabetic cataract. Oxidative stress leading to the expression of various enzymes has also been proven as crucial for cataractous changes in the lens in old age. A narrative review was undertaken to investigate the expression of different biochemical parameters as well as enzymes in diabetic and senile cataracts. Identification of these parameters is crucial for the prevention and treatment of blindness. Combinations of MeSH terms and key words were used to do literature search in PubMed. The search resulted 35 articles and among them, 13 were relevant to the topic and were included in synthesis of results. Seventeen different types of enzymes were identified in the senile and diabetic cataracts. Seven biochemical parameters were also identified. Alteration in biochemical parameters and expression of enzymes were comparable. Majority of the parameters were raised or altered in diabetic cataract compared to senile cataract.

Keywords: Age-related cataract; cataract; cataract enzymology; diabetic cataract; senile cataract.

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Conflict of interest statement

None

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References

    1. Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96:614–8. - PubMed
    1. Khairallah M, Kahloun R, Bourne R, Limburg H, Flaxman SR, Jonas JB, et al. Number of people blind or visually impaired by cataract worldwide and in world regions, 1990 to 2010. Investig Ophthalmol Vis Sci. 2015;56:6762–9. - PubMed
    1. Khanna RC, Murthy GVS, Giridhar P, Krishnaiah S, Pant HB, Palamaner Subash Shantha G, et al. Cataract, visual impairment and long-term mortality in a rural cohort in India: The Andhra Pradesh eye disease study. PLoS One. 2013;8:1–10. - PMC - PubMed
    1. Klein BEK, Klein R, Moss SE. Prevalence of cataracts in a population-based study of persons with diabetes mellitus. Ophthalmology. 1985;92:1191–6. - PubMed
    1. Drinkwater JJ, Davis WA, Davis TME. A systematic review of risk factors for cataract in type 2 diabetes. Diabetes Metab Res Rev. 2019;35 doi:10.1002/dmrr. 3073. - PubMed