Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Apr 6:37:45-48.
doi: 10.1016/j.jdcr.2023.03.013. eCollection 2023 Jul.

Cutaneous breast cancer of unknown primary

Iman Salem  1 , Raven Bennett  2 , Emma L Hodson  1 , Gabrielle E Duprat  1 , Hayden Doughty  2 , Natalia Georgantzoglou  3 , Konstantinos Linos  4 , Mary D Chamberlin  2 , M Shane Chapman  1   2
Affiliations
Case Reports

Cutaneous breast cancer of unknown primary

Iman Salem et al. JAAD Case Rep. .
No abstract available

Keywords: breast carcinoma; ectopic tissue; metastasis; next-generation sequencing; unknown primary.

PubMed Disclaimer

Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
A, Initial clinical presentation of cutaneous breast cancer of unknown primary. The figure shows a firm orange-pink 3.2-cm plaque on the right axilla. B, Axillary site 1 year after excision.
Fig 2
Fig 2
Invasive lobular breast carcinoma. A, A biopsy sample from the right axilla revealed a carcinoma directly invading into the dermis and epidermis without skin ulceration. B, Atypical epithelioid cells in between collagen bundles arranged singly and in cords. C, D, Immunohistochemistry stains for cytokeratin 7 and GATA-3 were positive. The tumor was also positive for estrogen receptor, BRST2, and mammaglobin, whereas it was negative for E-cadherin (not shown). The overall findings are compatible with a carcinoma of breast origin and lobular type. (A and B, Hematoxylin-eosin stain; C, cytokeratin 7 stain; D, GATA-3 stain; original magnifications: A, ×40; B, ×200; C, ×80; D, ×80.)
See this image and copyright information in PMC

References

    1. Lee M.S., Sanoff H.K. Cancer of unknown primary. BMJ. 2020;371 doi: 10.1136/bmj.m4050. - DOI - PubMed
    1. Salemis N.S. Primary ectopic breast carcinoma in the axilla: a rare presentation and review of the literature. Breast Dis. 2021;40(2):109–114. doi: 10.3233/BD-201027. - DOI - PubMed
    1. Alečković M., McAllister S.S., Polyak K. Metastasis as a systemic disease: molecular insights and clinical implications. Biochim Biophys Acta Rev Cancer. 2019;1872(1):89–102. doi: 10.1016/j.bbcan.2019.06.002. - DOI - PMC - PubMed
    1. Afifi A.M., Saad A.M., Al-Husseini M.J., Elmehrath A.O., Northfelt D.W., Sonbol M.B. Causes of death after breast cancer diagnosis: a US population-based analysis. Cancer. 2020;126(7):1559–1567. doi: 10.1002/cncr.32648. - DOI - PubMed
    1. Klein C.A. Parallel progression of primary tumours and metastases. Nat Rev Cancer. 2009;9(4):302–312. doi: 10.1038/nrc2627. - DOI - PubMed

Publication types