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Review
. 2023 May 31:10:1192131.
doi: 10.3389/fnut.2023.1192131. eCollection 2023.

Flavonoids improve type 2 diabetes mellitus and its complications: a review

Xinrui Yi  1 , Mosi Dong  1 , Naifei Guo  1 , Jinlong Tian  2 , Ping Lei  1 , Song Wang  3 , Yufeng Yang  1 , Yan Shi  1
Affiliations
Review

Flavonoids improve type 2 diabetes mellitus and its complications: a review

Xinrui Yi et al. Front Nutr. .

Abstract

The prevalence of type 2 diabetes mellitus (T2DM) is increasing every year. Medications are currently the most common therapy for T2DM. However, these medications have certain adverse effects. In order to find safe and effective ways to improve this disease, researchers have discovered that some natural products can decrease blood sugar. Flavonoids are one of the most essential low molecular weight phenolic chemicals in the plant world, which widely exist in plant roots, stems, leaves, flowers, and fruits. They possess a variety of biological activities, including organ protection, hypoglycemic, lipid-lowering, anti-oxidative and anti-inflammatory effects. Some natural flavonoids ameliorate T2DM and its complications through anti-oxidation, anti-inflammatory action, glucose and lipid metabolism regulation, insulin resistance management, etc. Hence, this review aims at demonstrating the potential benefits of flavonoids in T2DM and its complications. This laid the foundation for the development of novel hypoglycemic medications from flavonoids.

Keywords: Flavonoids; Inflammatory; T2DM; insulin resistance; oxidative stress.

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Conflict of interest statement

SW was employed by Liaoning Shengqi Haotian Biomedical Technology Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The basic structure of flavonoids.
Figure 2
Figure 2
High blood sugar levels cause insulin resistance.
Figure 3
Figure 3
Effects of oxidative stress on T2DM and its complications.
Figure 4
Figure 4
T2DM causes vascular endothelial damage and accelerates the progression of atherosclerosis.
Figure 5
Figure 5
Flavonoids for the treatment of DCM.
Figure 6
Figure 6
Flavonoids for the treatment of DN.
Figure 7
Figure 7
Flavonoids for the treatment of DR.
See this image and copyright information in PMC

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