Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 25;11(6):3385-3393.
doi: 10.1002/fsn3.3328. eCollection 2023 Jun.

Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females

Naveed Rasheed  1 , Aftab Ahmed  2 , Farhana Nosheen  1 , Ali Imran  3 , Fakhar Islam  3 , Rabia Noreen  1 , Anamika Chauhan  4 , Mohd Asif Shah  5 , Yuosra Amer Ali  6
Affiliations

Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females

Naveed Rasheed et al. Food Sci Nutr. .

Abstract

The formation and release of eggs during ovulation are impacted by high amounts of androgens. Seed cycling is powerful in the treatment of polycystic ovary syndrome (PCOS). For efficacy studies, 90 women with PCOS, between 15 and 40 years were selected from the department of gynecology, Tertiary care unit. Women with PCOS were divided into three groups (T0, T1, T2) (20 women/group). Among these three groups, the first was the control group (T0). The second group was the experimental group (T1). In T1, 20 women with PCOS were treated with a portion control diet and METFORMIN 500 mg tab/day for 90 days. The third group was also an experimental group (T2). In this group, 20 women with PCOS were also treated with another treatment plan for 90 days, in which portion control diet and seed cycling were included. During the 12-week efficacy trial, the highest follicle stimulating hormone (FSH) levels were found in the control group T0 (8.18 ± 0.13 mIU/mL). In T2, FSH falls from 6.545 ± 0.16 mIU/mL to 3.51 ± 0.13 mIU/mL throughout a 12-week period. Overall, a portion-controlled diet and seed cycling reduced FSH levels by 1.2% to 2.5%. LH value was 10.118 ± 0.1874 IU/L in the control group (T0), which climbed 12.82 ± 0.15 IU/L, but decreased from 10.62 ± 0.26 IU/L to 9.79 ± 0.17 U/L and 11.015 ± 0.24 IU/L 6.217 ± 0.167 IU/L in the other groups (T1, T2). It was determined that the LH levels were reduced by 1.5%-2% in T2. Conclusively, the seed cycling approach is effective and has significant results in women with PCOS. Seed cycling improves hormonal disturbance in women which promotes a healthy life.

Keywords: body mass index; endocrine; polycystic ovarian syndrome; seed cycling; ultrasound.

PubMed Disclaimer

Conflict of interest statement

Authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Seed cycling for women with polycystic ovary syndrome.
FIGURE 2
FIGURE 2
Flow sheet depicts the diet plan.
FIGURE 3
FIGURE 3
(a)Patient 1 with polycystic ovary (before and after seed cycling). (b) Patient 2 with polycystic ovary (before and after seed cycling). (c) Patient 3 with polycystic ovary (before and after seed cycling).
See this image and copyright information in PMC

References

    1. Ajith, D. M. (2022). Nutritional management of PCOS: A review article. Journal of Positive School Psychology, 6(8), 8979–8984.
    1. Alaee, S. , Mirani, M. , Derakhshan, Z. , Koohpeyma, F. , & Bakhtari, A. (2023). Thymoquinone improves folliculogenesis, sexual hormones, gene expression of apoptotic markers and antioxidant enzymes in polycystic ovary syndrome rat model. Veterinary Medicine and Science, 9, 290–300. 10.1002/vms3.958 - DOI - PMC - PubMed
    1. Amini, L. , Tehranian, N. , Movahedin, M. , Tehrani, F. R. , & Ziaee, S. (2015). Antioxidants and management of polycystic ovary syndrome in Iran: A systematic review of clinical trials. Iranian Journal of Reproductive Medicine, 13(1), 1–8. - PMC - PubMed
    1. Azin, F. , & Khazali, H. (2022). Phytotherapy of polycystic ovary syndrome: A review. International Journal of Reproductive BioMedicine, 20(1), 13–20. - PMC - PubMed
    1. Bedigian, D. (2004). History and lore of sesame in Southwest Asia. Economic Botany, 58(3), 329–353.