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Review
. 2023 Apr 19;11(2):135-150.
doi: 10.5599/admet.1711. eCollection 2023.

Recent advances in electrochemical determination of anticancer drug 5-fluorouracil

Totka Dodevska  1 , Dobrin Hadzhiev  1 , Ivan Shterev  1
Affiliations
Review

Recent advances in electrochemical determination of anticancer drug 5-fluorouracil

Totka Dodevska et al. ADMET DMPK. .

Abstract

Reliable, rapid, highly selective and sensitive analytical methods for the determination of antineoplastic agent 5-fluorouracil (5-FU) in human body fluids (blood serum/plasma and urine) are required to improve the chemotherapy regimen to reduce its toxicity and improve efficacy. Nowadays, electrochemical techniques provide a powerful analytical tool for 5-FU detection systems. This comprehensive review covers the advances in the development of electrochemical sensors for the quantitative determination of 5-FU, mainly focused on original studies reported from 2015 to date. We have summarized recent trends in the electrochemical sensor systems applied for the analysis of 5-FU in pharmaceutical formulations and biological samples, and critically evaluated the key performance metrics of these sensors (limit of detection, linear range, stability and recovery). Challenges and future outlooks in this field have also been discussed.

Keywords: Electrochemical detection; analysis; cancer; electroanalysis; pharmaceutical electrochemistry; sensor.

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Conflict of interest statement

Conflict of interest: The author declares no conflict of interest.

Figures

Figure 1.
Figure 1.
Illustrative representation of electrochemical detection of 5-FU.
See this image and copyright information in PMC

References

    1. Longley D., Harkin D., Johnston P.. 5-Fluorouracil: mechanisms of action and clinical strategies. Nature Reviews Cancer 3 (2003) 330-338. https://doi.org/10.1038/nrc1074 10.1038/nrc1074 - DOI - PubMed
    1. Heggie G.D., Sommadossi J.P., Cross D.S., Huster W.J., Diasio R.B.. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Research 47 (1987) 2203-2206. https://aacrjournals.org/cancerres/article-pdf/47/8/2203/2430813/cr04700... - PubMed
    1. Breda M., Barattè S.. A review of analytical methods for the determination of 5-fluorouracil in biological matrices. Analytical and Bioanalytical Chemistry 397(3) (2010) 1191-1201. https://doi.org/10.1007/s00216-010-3633-8 10.1007/s00216-010-3633-8 - DOI - PubMed
    1. Diasio R.B., Harris B.E.. Clinical Pharmacology of 5-Fluorouracil. Clinical Pharmacokinetics 16(4) (1989) 215-237. https://doi.org/10.2165/00003088-198916040-00002 10.2165/00003088-198916040-00002 - DOI - PubMed
    1. Kadoyama K., Miki I., Tamura T., Brown J.B., Sakaeda T., Okuno Y.. Adverse event profiles of 5-fluorouracil and capecitabine: data mining of the public version of the FDA Adverse Event Reporting System, AERS, and reproducibility of clinical observations. International Journal of Medical Sciences 9(1) (2012) 33-39. https://doi.org/10.7150/ijms.9.33 10.7150/ijms.9.33 - DOI - PMC - PubMed

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