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. 2023 Jun;9(3):165-168.
doi: 10.1159/000528658. Epub 2023 Feb 20.

Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa

Michela Iannone  1 , Giorgia Salvia  1 , Cristian Fidanzi  1 , Matteo Bevilacqua  2 , Agata Janowska  1 , Riccardo Morganti  2 , Marco Romanelli  1 , Valentina Dini  1
Affiliations

Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa

Michela Iannone et al. Skin Appendage Disord. 2023 Jun.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Skin Appendage Disord. 2024 Aug;10(4):333. doi: 10.1159/000539351. Epub 2024 Jun 13. Skin Appendage Disord. 2024. PMID: 39210940 Free PMC article.

Abstract

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic inflammation and high impact on quality of life. Treatment strategies are still inadequate with a lack of inflammation biomarkers. We conducted a prospective study to assess the correlation between serum amyloid A (SAA) levels and active lesion count; disease severity; Dermatology Life Quality Index (DLQI); smoking; BMI; and lesion sites.

Methods: Forty-one patients (M/F: 22/19) were enrolled. Demographic, clinical, laboratory, and therapeutic data were assessed at baseline on patients not under treatment or in wash-out from systemic treatment for at least 2 weeks. Associations were investigated by univariate and multivariate analyses.

Results: SAA levels were significantly associated with number of nodules (p = 0.005), abscesses (p < 0.001), fistulas (p = 0.016), and severe IHS4 (p = 0.088 and r = 0.514). Gluteal localization was correlated with high values of mSartorius and severe IHS4.

Conclusions: We recommend assessment of SAA levels to monitor therapeutic response in patient with HS in order to prevent disease's flare and potential complications.

Keywords: Acne inversa; Biomarker; Hidradenitis suppurativa; Inflammation; Inflammatory skin disease; Serum amyloid A.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Fig. 1
Fig. 1
Correlation between gluteal localization and mSartorius/IHS4.
See this image and copyright information in PMC

References

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