Review

. 2023 Sep;30(9):2899-2911.

doi: 10.1111/ene.15928. Epub 2023 Jun 29.

Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

Marion Pépin^{1

2}, Aleksandra Klimkowicz-Mrowiec³, Olivier Godefroy⁴, Pilar Delgado⁵, Sol Carriazo⁶, Ana Carina Ferreira^{7

8}, Aleksandra Golenia⁹, Jolanta Malyszko¹⁰, Tomasz Grodzicki³, Konstantinos Giannakou¹¹, Giuseppe Paolisso^{12

13}, Michelangela Barbieri¹², Liliana Garneata¹⁴, Carmen Antonia Mocanu¹⁴, Sophie Liabeuf^{15

16}, Goce Spasovski¹⁷, Carmine Zoccali^{18

19}, Annette Bruchfeld^{20

21}, Ana Farinha²², Mustafa Arici²³, Giovambattista Capasso^{24

25}, Andrzej Wiecek²⁶, Ziad A Massy^{1

27}; CONNECT (Cognitive Decline in Nephro-Neurology: European Cooperative Target) Action

Collaborators, Affiliations

Collaborators

CONNECT (Cognitive Decline in Nephro-Neurology: European Cooperative Target) Action:
Alexandre Andrade, Maie Bachmann, Inga Bumblyte, Adrian Constantin Covic, Nicole Endlich, Andreas Engvig, Denis Fouque, Casper Franssen, Sebastian Frische, Loreto Gesualdo, Dimitrios Goumenos, Laila-Yasmin Mani, Hans-Peter Marti, Christopher Mayer, Rikke Nielsen, Vesna Pešić, Merita Rroji Molla, Giorgos Sakkas, Kate Stevens, Evgueniy Vazelov, Davide Viggiano, Lefteris Zacharia, Ewout Hoorn, Andreja Figurek, Robert Unwin, Carsten Alexander Wagner, Christoph Wanner, Dorothea Nitsch, Ivo Fridolin, Gaye Hafez, Maria José Soler Romeo, Bojan Batinić, Laura Carrasco, Ron Gansevoort, Gianvito Martino, Francesco Mattace Raso, Ionut Nistor, Alberto Ortiz, Daiva Rastenytė, Gabriel Stefan, Gioacchino Tedeschi, Boris Bikbov, Karl Hans Endlich, Justina Kurganaite, Norberto Perico, Giuseppe Remuzzi, Francesco Trepiccione, Peter Blankestijn, Kai-Uwe Eckardt, Danilo Fliser, Eugenio Gutiérrez-Jiménez, Maximilian Konig, Ivan Rychlik, Michela Deleidi, George Reusz, Michele Farisco, Norberto Perico, Pedro Henrique Imenez Silva, Mickaël Bobot, Giovanna Capolongo

Affiliations

¹ INSERM (Institut National de la Santé et de la recherche médicale) Unit 1018, Clinical Epidemiology, CESP (Centre d'Epidemiologie et de Santé des Populations), Hôpital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University, Villejuif, France.
² Department of Geriatrics, Ambroise Paré University Hospital, APHP (Assistance Publique - Hôpitaux de Paris), Boulogne-Billancourt/Paris, France.
³ Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Cracow, Poland.
⁴ Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (Research Unit 4559), Jules Verne University of Picardie (UPJV), Amiens, France.
⁵ Department of Neurology, Vall d'Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain.
⁶ Department of Nephrology and Hypertension, Instituto de Investigacion Sanitaria (IIS)-Fundacion Jimenez Diaz, Autonomous University of Madrid (UAM), Madrid, Spain.
⁷ Department of Nephrology, Centro Hospitalar e Universitário de Lisboa Central-Hospital Curry Cabral, Lisbon, Portugal.
⁸ Universidade Nova de Lisboa-Faculdade de Ciências Médicas-Nephology, Lisbon, Portugal.
⁹ Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
¹⁰ Department of Nephrology, Dialysis, and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
¹¹ Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus.
¹² Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
¹³ UniCAMILLUS, International Medical University, Roma, Italy.
¹⁴ Department of Internal Medicine and Nephrology, "Carol Davila" University of Medicine and Pharmacy, "Dr Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
¹⁵ Pharmacology Department, Amiens University Medical Center, Amiens, France.
¹⁶ MP3CV (Mécanismes physiopathologiques et Conséquences des Calcifications Cardio-Vasculaires) Laboratory, EA7517, University of Picardie Jules Verne, Amiens, France.
¹⁷ University Department of Nephrology, Clinical Center "Mother Theresa", University of Saints Cyril and Methodius, Skopje, North Macedonia.
¹⁸ Renal Research Institute, New York, New York, USA.
¹⁹ Associazione Ipertensione Nefrologia Trapianto Renale, Reggio Calabria, Italy.
²⁰ Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
²¹ CLINTEC, Renal Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
²² Department of Nephrology, Centro Hospitalar de Setúbal, Setubal, Portugal.
²³ Department of Internal Medicine, Division of Nephrology, Hacetepe University, Faculty of Medicine, Ankara, Turkey.
²⁴ Biogem (Molecular Biology and Genetics Research Institute), Ariano Irpino, Italy.
²⁵ Department of Translational Medical Sciences, University of Campania, Naples, Italy.
²⁶ Department of Nephrology, Transplantation, and Internal Medicine, Medical University of Silesia in Katowice, Katowice, Poland.
²⁷ Department of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, France.

PMID: 37326125
DOI: 10.1111/ene.15928

Free article

Review

Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

Marion Pépin et al. Eur J Neurol. 2023 Sep.

Free article

. 2023 Sep;30(9):2899-2911.

doi: 10.1111/ene.15928. Epub 2023 Jun 29.

Authors

Collaborators

CONNECT (Cognitive Decline in Nephro-Neurology: European Cooperative Target) Action:
Alexandre Andrade, Maie Bachmann, Inga Bumblyte, Adrian Constantin Covic, Nicole Endlich, Andreas Engvig, Denis Fouque, Casper Franssen, Sebastian Frische, Loreto Gesualdo, Dimitrios Goumenos, Laila-Yasmin Mani, Hans-Peter Marti, Christopher Mayer, Rikke Nielsen, Vesna Pešić, Merita Rroji Molla, Giorgos Sakkas, Kate Stevens, Evgueniy Vazelov, Davide Viggiano, Lefteris Zacharia, Ewout Hoorn, Andreja Figurek, Robert Unwin, Carsten Alexander Wagner, Christoph Wanner, Dorothea Nitsch, Ivo Fridolin, Gaye Hafez, Maria José Soler Romeo, Bojan Batinić, Laura Carrasco, Ron Gansevoort, Gianvito Martino, Francesco Mattace Raso, Ionut Nistor, Alberto Ortiz, Daiva Rastenytė, Gabriel Stefan, Gioacchino Tedeschi, Boris Bikbov, Karl Hans Endlich, Justina Kurganaite, Norberto Perico, Giuseppe Remuzzi, Francesco Trepiccione, Peter Blankestijn, Kai-Uwe Eckardt, Danilo Fliser, Eugenio Gutiérrez-Jiménez, Maximilian Konig, Ivan Rychlik, Michela Deleidi, George Reusz, Michele Farisco, Norberto Perico, Pedro Henrique Imenez Silva, Mickaël Bobot, Giovanna Capolongo

Affiliations

¹ INSERM (Institut National de la Santé et de la recherche médicale) Unit 1018, Clinical Epidemiology, CESP (Centre d'Epidemiologie et de Santé des Populations), Hôpital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University, Villejuif, France.
² Department of Geriatrics, Ambroise Paré University Hospital, APHP (Assistance Publique - Hôpitaux de Paris), Boulogne-Billancourt/Paris, France.
³ Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Cracow, Poland.
⁴ Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (Research Unit 4559), Jules Verne University of Picardie (UPJV), Amiens, France.
⁵ Department of Neurology, Vall d'Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain.
⁶ Department of Nephrology and Hypertension, Instituto de Investigacion Sanitaria (IIS)-Fundacion Jimenez Diaz, Autonomous University of Madrid (UAM), Madrid, Spain.
⁷ Department of Nephrology, Centro Hospitalar e Universitário de Lisboa Central-Hospital Curry Cabral, Lisbon, Portugal.
⁸ Universidade Nova de Lisboa-Faculdade de Ciências Médicas-Nephology, Lisbon, Portugal.
⁹ Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
¹⁰ Department of Nephrology, Dialysis, and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
¹¹ Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus.
¹² Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
¹³ UniCAMILLUS, International Medical University, Roma, Italy.
¹⁴ Department of Internal Medicine and Nephrology, "Carol Davila" University of Medicine and Pharmacy, "Dr Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
¹⁵ Pharmacology Department, Amiens University Medical Center, Amiens, France.
¹⁶ MP3CV (Mécanismes physiopathologiques et Conséquences des Calcifications Cardio-Vasculaires) Laboratory, EA7517, University of Picardie Jules Verne, Amiens, France.
¹⁷ University Department of Nephrology, Clinical Center "Mother Theresa", University of Saints Cyril and Methodius, Skopje, North Macedonia.
¹⁸ Renal Research Institute, New York, New York, USA.
¹⁹ Associazione Ipertensione Nefrologia Trapianto Renale, Reggio Calabria, Italy.
²⁰ Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
²¹ CLINTEC, Renal Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
²² Department of Nephrology, Centro Hospitalar de Setúbal, Setubal, Portugal.
²³ Department of Internal Medicine, Division of Nephrology, Hacetepe University, Faculty of Medicine, Ankara, Turkey.
²⁴ Biogem (Molecular Biology and Genetics Research Institute), Ariano Irpino, Italy.
²⁵ Department of Translational Medical Sciences, University of Campania, Naples, Italy.
²⁶ Department of Nephrology, Transplantation, and Internal Medicine, Medical University of Silesia in Katowice, Katowice, Poland.
²⁷ Department of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt/Paris, France.

PMID: 37326125
DOI: 10.1111/ene.15928

Abstract

Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition.

Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives.

Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce.

Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.

Keywords: chronic kidney disease; cognition; dialysis; glomerular filtration rate; vascular risk factors.

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References

REFERENCES

1. Etgen T, Chonchol M, Förstl H, Sander D. Chronic kidney disease and cognitive impairment: a systematic review and meta-analysis. Am J Nephrol. 2012;35(5):474-482. doi:10.1159/000338135
1. Berger I, Wu S, Masson P, et al. Cognition in chronic kidney disease: a systematic review and meta-analysis. BMC Med. 2016;14(1):206. doi:10.1186/s12916-016-0745-9
1. O'Lone E, Connors M, Masson P, et al. Cognition in people with end-stage kidney disease treated with hemodialysis: a systematic review and meta-analysis. Am J Kidney Dis. 2016;67(6):925-935. doi:10.1053/j.ajkd.2015.12.028
1. Drew DA, Weiner DE, Sarnak MJ. Cognitive impairment in CKD: pathophysiology, management, and prevention. Am J Kidney Dis. 2019;74:782-790. doi:10.1053/j.ajkd.2019.05.017
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Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

Collaborators

Affiliations

Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

Authors

Collaborators

Affiliations

Abstract

References

REFERENCES

Publication types

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LinkOut - more resources

Full Text Sources

Medical