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Review
. 2023 Jun 23;8(84):eadh2967.
doi: 10.1126/sciimmunol.adh2967. Epub 2023 Jun 16.

Reversing the mitochondrial hex that bewitches NLRP3

Manasa Mellacheruvu  1 , Grace M E P Lawrence  1 , Stefan Emming  1 , Kate Schroder  1
Affiliations
Review

Reversing the mitochondrial hex that bewitches NLRP3

Manasa Mellacheruvu et al. Sci Immunol. .

Abstract

Hexokinase dissociation from mitochondria triggers calcium-induced oligomerization of VDAC within the outer mitochondrial membrane, leading to NLRP3 recruitment and inflammasome signaling (see related Research Article by Baik et al.).

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