Stressing the role of a short linear motif in ataxin-2 condensation
- PMID: 37327772
- DOI: 10.1016/j.molcel.2023.05.024
Stressing the role of a short linear motif in ataxin-2 condensation
Abstract
Ataxin-2, an RNA-binding protein that is conserved across eukaryotes, is involved in stress granule assembly and age-associated neurodegenerative diseases. In this issue of Molecular Cell, Boeynaems et al.1 identify a short linear motif in ataxin-2 as a condensation switch, providing molecular insights into its essential role in cellular stress response.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.Mol Cell. 2023 Jun 15;83(12):2020-2034.e6. doi: 10.1016/j.molcel.2023.05.025. Epub 2023 Jun 8. Mol Cell. 2023. PMID: 37295429 Free PMC article.
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