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Comment
. 2023 Jun 15;83(12):1964-1966.
doi: 10.1016/j.molcel.2023.05.032.

CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes

Chaithanya P Vedula  1 , Neil J Ganem  2
Affiliations
Free article
Comment

CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes

Chaithanya P Vedula et al. Mol Cell. .
Free article

Abstract

Lin et al.1 demonstrate that acentric chromosome fragments generated within micronuclei are tethered by the CIP2A-TOPBP1 complex during mitosis, thus promoting clustered segregation of the fragments to a single daughter cell nucleus and facilitating re-ligation with limited chromosomal scattering and loss.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Mitotic clustering of pulverized chromosomes from micronuclei.
    Lin YF, Hu Q, Mazzagatti A, Valle-Inclán JE, Maurais EG, Dahiya R, Guyer A, Sanders JT, Engel JL, Nguyen G, Bronder D, Bakhoum SF, Cortés-Ciriano I, Ly P. Lin YF, et al. Nature. 2023 Jun;618(7967):1041-1048. doi: 10.1038/s41586-023-05974-0. Epub 2023 May 10. Nature. 2023. PMID: 37165191 Free PMC article.

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