Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Jul 11;35(7):1099-1100.
doi: 10.1016/j.cmet.2023.06.002. Epub 2023 Jun 15.

Extracellular HSP90 warms up integrins for an irisin workout

Dimitra Bourboulia  1 , Mark R Woodford  2 , Mehdi Mollapour  3
Affiliations
Comment

Extracellular HSP90 warms up integrins for an irisin workout

Dimitra Bourboulia et al. Cell Metab. .

Abstract

The hormone-like protein irisin is involved in browning of adipose tissue and regulation of metabolism. Recently, Mu et al. identified the extracellular chaperone heat shock protein-90 (Hsp90) as the activating factor for "opening" αVβ5 integrin receptor, allowing for high-affinity irisin binding and effective signal transduction.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.. Extracellular chaperone Hsp90 “warms up” integrin for irisin workout
Physical exercise leads to an increase in irisin levels as well as release of the molecular chaperone Hsp90. Irisin alone has low affinity for the closed state of αVβ5 integrin receptor. Extracellular Hsp90 (eHsp90) “opens” αVβ5, allowing for irisin binding with high-affinity and effective signal transduction through its integrin receptor.
See this image and copyright information in PMC

Comment on

  • Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.
    A M, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, Sebastian L, Gygi SP, Arthanari H, Dhe-Paganon S, Griffin PR, Engen JR, Spiegelman BM. A M, et al. Mol Cell. 2023 Jun 1;83(11):1903-1920.e12. doi: 10.1016/j.molcel.2023.05.008. Mol Cell. 2023. PMID: 37267907 Free PMC article.

References

    1. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP, and Holloszy JO (2002). Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 16, 1879–1886. 10.1096/fj.02-0367com. - DOI - PubMed
    1. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, et al. (2012). A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463–468. 10.1038/nature10777. - DOI - PMC - PubMed
    1. Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, et al. (2021). Exercise hormone irisin is a critical regulator of cognitive function. Nat. Metab 3, 1058–1070. 10.1038/s42255-021-00438-z. - DOI - PMC - PubMed
    1. Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VJA, Novick SJ, et al. (2018). Irisin mediates effects on bone and fat via alphaV integrin receptors. Cell 175, 1756–1768.e17. 10.1016/j.cell.2018.10.025. - DOI - PMC - PubMed
    1. Mu A, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, et al. (2023). Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90a. Mol. Cell 83, 1903–1920.e12. 10.1016/j.molcel.2023.05.008. - DOI - PMC - PubMed

Publication types