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Review
. 2023 Aug;101(8):917-929.
doi: 10.1007/s00109-023-02337-0. Epub 2023 Jun 17.

TFEB: a double-edged sword for tumor metastasis

Jun-Hu Hu #  1   2 , Shou-Ye Li #  3   4 , Li-Hua Yu  1   2 , Zhen-Rong Guan  1   2 , Ya-Ping Jiang  1   2 , Die Hu  1   2 , Hao-Jie Wang  1   2 , Li-Ping Zhao  1   2 , Zhao-Huang Zhou  1   2 , Ya-Xin Yan  1   2 , Tian Xie  5   6 , Zhi-Hui Huang  7   8 , Jian-Shu Lou  9   10
Affiliations
Review

TFEB: a double-edged sword for tumor metastasis

Jun-Hu Hu et al. J Mol Med (Berl). 2023 Aug.

Abstract

Transcription factor EB, a member of the microphthalmia-associated transcription factor (MiTF/TFE) family, is a master regulator of autophagy, lysosome biogenesis, and TAMs. Metastasis is one of the main reasons for the failure of tumor therapy. Studies on the relationship between TFEB and tumor metastasis are contradictory. On the positive side, TFEB mainly affects tumor cell metastasis via five aspects, including autophagy, epithelial-mesenchymal transition (EMT), lysosomal biogenesis, lipid metabolism, and oncogenic signaling pathways; on the negative side, TFEB mainly affects tumor cell metastasis in two aspects, including tumor-associated macrophages (TAMs) and EMT. In this review, we described the detailed mechanism of TFEB-mediated regulation of metastasis. In addition, we also described the activation and inactivation of TFEB in several aspects, including the mTORC1 and Rag GTPase systems, ERK2, and AKT. However, the exact process by which TFEB regulates tumor metastasis remains unclear in some pathways, which requires further studies.

Keywords: Activation; Metastasis; Phosphorylation; TFEB; Tumor.

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