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. 2023 Oct 18;228(8):1089-1098.
doi: 10.1093/infdis/jiad216.

Genetic Profiling of Plasmodium ovale wallikeri Relapses With Microsatellite Markers and Whole-Genome Sequencing

Valentin Joste  1   2 , Emma Colard-Itté  2 , Émilie Guillochon  1 , Frédéric Ariey  3 , Romain Coppée  4 , Jérôme Clain  1   2 , Sandrine Houzé  1   2 ; French National Reference Center for Imported Malaria Study Group
Collaborators, Affiliations

Genetic Profiling of Plasmodium ovale wallikeri Relapses With Microsatellite Markers and Whole-Genome Sequencing

Valentin Joste et al. J Infect Dis. .

Abstract

Like Plasmodium vivax, both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitemia originating from liver-dormant forms subsequent to a primary infection. Here, we investigated relapse patterns in P ovale wallikeri infections from a cohort of travelers who were exposed to the parasite in sub-Saharan Africa and then experienced relapses after their return to France. Using a novel set of 8 highly polymorphic microsatellite markers, we genotyped 15 P ovale wallikeri relapses. For most relapses, the paired primary and relapse infections were highly genetically related (with 12 being homologous), an observation that was confirmed by whole-genome sequencing for the 4 relapses we further studied. This is, to our knowledge, the first genetic evidence of relapses in P ovale spp.

Keywords: Plasmodium ovale wallikeri; WGS; microsatellites; relapses; sWGA.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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