Volatile versus intravenous anaesthesia and perioperative neurocognitive disorders: anything to see here?

Lisbeth A Evered¹, David A Scott², Robert Sanders³

Affiliations

¹ Department of Critical Care, School of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Anaesthesia and Acute Pain Medicine, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia; Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA. Electronic address: lae4004@med.cornell.edu.
² Department of Critical Care, School of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Anaesthesia and Acute Pain Medicine, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia.
³ Department of Anaesthetics & Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia; NHMRC Clinical Trials Centre & Central Clinical School, The University of Sydney, Sydney, NSW, Australia.

PMID: 37330310
DOI: 10.1016/j.bja.2023.05.018

Free article

Editorial

Volatile versus intravenous anaesthesia and perioperative neurocognitive disorders: anything to see here?

Lisbeth A Evered et al. Br J Anaesth. 2023 Aug.

Free article

. 2023 Aug;131(2):191-193.

doi: 10.1016/j.bja.2023.05.018. Epub 2023 Jun 15.

Authors

Lisbeth A Evered¹, David A Scott², Robert Sanders³

Affiliations

¹ Department of Critical Care, School of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Anaesthesia and Acute Pain Medicine, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia; Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA. Electronic address: lae4004@med.cornell.edu.
² Department of Critical Care, School of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Anaesthesia and Acute Pain Medicine, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia.
³ Department of Anaesthetics & Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia; NHMRC Clinical Trials Centre & Central Clinical School, The University of Sydney, Sydney, NSW, Australia.

PMID: 37330310
DOI: 10.1016/j.bja.2023.05.018

Abstract

There is a potential differential effect of sevoflurane compared with propofol on postoperative delirium and other perioperative neurocognitive disorders. More generally, there are perhaps differences between volatile and intravenous anaesthetic agents in their possible impact on perioperative neurocognitive disorders. Strengths and limitations of a recent study in this journal and its contribution to our understanding of the impact of anaesthetic technique on perioperative neurocognitive disorders are discussed.

Keywords: general anaesthesia; perioperative neurocognitive disorders; postoperative delirium; propofol; sevoflurane; total intravenous anaesthesia; volatile anaesthesia.

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Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies.
Wang E, Belley-Côté EP, Young J, He H, Saud H, D'Aragon F, Um K, Alhazzani W, Piticaru J, Hedden M, Whitlock R, Mazer CD, Kashani HH, Zhang SY, Lucas A, Timmerman N, Nishi C, Jain D, Kugler A, Beaver C, Kloppenburg S, Schulman S, Borges FK, Kavosh M, Wada C, Lin S, Sibilio S, Lauw M, Benz A, Szczeklik W, Mokhtari A, Jacobsohn E, Spence J. Wang E, et al. Br J Anaesth. 2023 Aug;131(2):302-313. doi: 10.1016/j.bja.2022.12.001. Epub 2023 Jan 6. Br J Anaesth. 2023. PMID: 36621439
Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial.
Cao SJ, Zhang Y, Zhang YX, Zhao W, Pan LH, Sun XD, Jia Z, Ouyang W, Ye QS, Zhang FX, Guo YQ, Ai YQ, Zhao BJ, Yu JB, Liu ZH, Yin N, Li XY, Ma JH, Li HJ, Wang MR, Sessler DI, Ma D, Wang DX; First Study of Perioperative Organ Protection (SPOP1) investigators. Cao SJ, et al. Br J Anaesth. 2023 Aug;131(2):253-265. doi: 10.1016/j.bja.2023.04.024. Epub 2023 Jun 4. Br J Anaesth. 2023. PMID: 37474241

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Volatile versus intravenous anaesthesia and perioperative neurocognitive disorders: anything to see here?

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Volatile versus intravenous anaesthesia and perioperative neurocognitive disorders: anything to see here?

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