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. 2023 Sep;53(6):104738.
doi: 10.1016/j.idnow.2023.104738. Epub 2023 Jun 17.

Otorrhea bacterial profile, epidemiology before widespread use of the third-generation pneumococcal conjugate vaccine in French children, a prospective study from 2015 to 2023

Corinne Levy  1 , Emmanuelle Varon  2 , Philippe Bidet  3 , Stéphane Béchet  4 , Christophe Batard  4 , Alain Wollner  4 , Franck Thollot  4 , Stéphane Bonacorsi  3 , Robert Cohen  5
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Free article

Otorrhea bacterial profile, epidemiology before widespread use of the third-generation pneumococcal conjugate vaccine in French children, a prospective study from 2015 to 2023

Corinne Levy et al. Infect Dis Now. 2023 Sep.
Free article

Abstract

Objectives: The aim of this study was to describe the bacterial profile of middle ear fluid from spontaneous perforation of the tympanic membrane (SPTM) prior to widespread utilization of third- generation pneumococcal conjugate vaccines (PCVs).

Patients and methods: From October 2015 to January 2023, children with SPTM were prospectively enrolled by pediatricians.

Results: Among the 852 children with SPTM, 73.2% were less than 3 years old; more frequently than older children, they were and suffering from complex acute otitis media (AOM) (27.9%) and conjunctivitis (13.1%). In children under 3 years of age, NT Haemophilus influenzae (49.7%) was the main otopathogen isolated, particularly in those with complex AOM (57.1%). In children over 3 years of age, Group A Streptococcus accounted for 57%. In pneumococcal cases (25.1%), serotype 3 was the main serotype isolated (16.2%), followed by 23B (15.2%).

Conclusion: Our data from 2015 to 2023 represent a robust baseline preceding the widespread utilization of next-generation PCVs.

Keywords: Group A Streptococcus; Heamophilus influenzae; Otorrhea; Pneumococcal conjugate vaccines; Streptococcus pneumoniae.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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