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Review
. 2023 Aug;49(3):563-584.
doi: 10.1016/j.rdc.2023.03.006.

Therapeutic Advances in Eosinophilic Granulomatosis with Polyangiitis

Jessica L Bloom  1 , Carol A Langford  2 , Michael E Wechsler  3
Affiliations
Review

Therapeutic Advances in Eosinophilic Granulomatosis with Polyangiitis

Jessica L Bloom et al. Rheum Dis Clin North Am. 2023 Aug.

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic vasculitis that affects a variety of organ systems. Historically, glucocorticoids and a variety of other immunosuppressants were used to abrogate the inflammation and tissue injury associated with EGPA. The management of EGPA has evolved greatly during the last decade with the development of novel targeted therapeutics that have resulted in significantly improved outcomes for these patients, with many more novel targeted therapies emerging.

Keywords: ANCA-associated vasculitis; Anti-IL-5; Churg-Strauss; EGPA; Eosinophilia; Mepolizumab; Therapeutics.

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