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Review
. 2023 Jul;33(3):287-297.
doi: 10.1016/j.semradonc.2023.03.006.

[18F]FDG-PET-Based Personalized Radiotherapy Dose Prescription

Johannes H A M Kaanders  1 , Johan Bussink  2 , Erik H J G Aarntzen  3 , Pètra Braam  2 , Heidi Rütten  2 , Richard W M van der Maazen  2 , Marcel Verheij  2 , Sven van den Bosch  2
Affiliations
Free article
Review

[18F]FDG-PET-Based Personalized Radiotherapy Dose Prescription

Johannes H A M Kaanders et al. Semin Radiat Oncol. 2023 Jul.
Free article

Abstract

PET imaging with 2'-deoxy-2'-[18F]fluoro-D-glucose ([18F]FDG) has become one of the pillars in the management of malignant diseases. It has proven value in diagnostic workup, treatment policy, follow-up, and as prognosticator for outcome. [18F]FDG is widely available and standards have been developed for PET acquisition protocols and quantitative analyses. More recently, [18F]FDG-PET is also starting to be appreciated as a decision aid for treatment personalization. This review focuses on the potential of [18F]FDG-PET for individualized radiotherapy dose prescription. This includes dose painting, gradient dose prescription, and [18F]FDG-PET guided response-adapted dose prescription. The current status, progress, and future expectations of these developments for various tumor types are discussed.

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