A Rare Case of Kikuchi-Fujimoto Disease

Abstract

Kikuchi-Fujimoto disease (KFD) is an autoimmune condition that is more common in females and occurs in the third decade of life. The condition is usually benign and self-resolving and is characterized by fever, cervical lymphadenopathy, night sweats, myalgia, and rashes. The disease can be misdiagnosed as reactive follicular hyperplasia, tuberculous lymphadenitis, systemic lupus erythematosus, and malignant lymphoma. The diagnosis of KFD involves the excision of the affected lymph node. Although there is no specific treatment for the disease, usually symptomatic and supportive measures are effective; however, steroids and immunosuppressive therapies are considered in more severe cases. The disease lasts for around one to four months. The neurological complications include cerebellar ataxia, meningoencephalitis, and aseptic meningitis. Here, we describe the case of a 36-year-old male who presented with complaints of fever, malaise chills, anorexia, and fatigue associated with a tender right axillary lymph node. The patient underwent a biopsy which confirmed KFD and responded well to supportive therapy.

Keywords: autoimmune disease; kikuchi disease; kikuchi-fujimoto disease (kfd); necrotizing lymphadenitis; syndrome of fever of unknown origin.

Figure 1. The affected nodes show focal well-circumscribed, paracortical, necrotizing lesions.

Figure 2. Abundant karyorrhectic debris, scattered fibrin deposits, and collections of large mononuclear cells.