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Review
. 2023 Jun 1:16:1199313.
doi: 10.3389/fnmol.2023.1199313. eCollection 2023.

Remyelination in multiple sclerosis from the miRNA perspective

Karina Maciak  1 , Angela Dziedzic  1 , Joanna Saluk  1
Affiliations
Review

Remyelination in multiple sclerosis from the miRNA perspective

Karina Maciak et al. Front Mol Neurosci. .

Abstract

Remyelination relies on the repair of damaged myelin sheaths, involving microglia cells, oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes. This process drives the pathophysiology of autoimmune chronic disease of the central nervous system (CNS), multiple sclerosis (MS), leading to nerve cell damage and progressive neurodegeneration. Stimulating the reconstruction of damaged myelin sheaths is one of the goals in terms of delaying the progression of MS symptoms and preventing neuronal damage. Short, noncoding RNA molecules, microRNAs (miRNAs), responsible for regulating gene expression, are believed to play a crucial role in the remyelination process. For example, studies showed that miR-223 promotes efficient activation and phagocytosis of myelin debris by microglia, which is necessary for the initiation of remyelination. Meanwhile, miR-124 promotes the return of activated microglia to the quiescent state, while miR-204 and miR-219 promote the differentiation of mature oligodendrocytes. Furthermore, miR-138, miR-145, and miR-338 have been shown to be involved in the synthesis and assembly of myelin proteins. Various delivery systems, including extracellular vesicles, hold promise as an efficient and non-invasive way for providing miRNAs to stimulate remyelination. This article summarizes the biology of remyelination as well as current challenges and strategies for miRNA molecules in potential diagnostic and therapeutic applications.

Keywords: demyelination; miRNA; microRNA; multiple sclerosis; myelin; oligodendrocyte; oligodendrocyte precursor cells; remyelination.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Summary of the miRNAs associated with different phases of the remyelination process. In the figure, miRNAs that have a positive impact on a particular stage of remyelination are shown in green, whereas miRNAs that have a negative effect on a particular stage of remyelination are shown in red. (A) Clearance of myelin debris and secreted of factors by microglia. (B) OPCs recruitment and proliferation. (C) OPCs differentiation and maturation. (D) Myelin proteins assembly. OPCs, Oligodendrocyte Precursor Cells (OPCs); OLs, oligodendrocytes.
See this image and copyright information in PMC

References

    1. Aparicio E., Mathieu P., Pereira Luppi M., Almeira Gubiani M. F., Adamo A. M. (2013). The notch signaling pathway: its role in focal CNS demyelination and apotransferrin-induced remyelination. J. Neurochem. 127, 819–836. doi: 10.1111/jnc.12440, PMID: - DOI - PubMed
    1. Arranz L., De Castro N. M., Baeza I., Maté I., Viveros M. P., De la Fuente M. (2010). Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice. Rejuvenation Res. 13, 415–428. doi: 10.1089/rej.2009.0989, PMID: - DOI - PubMed
    1. Atlas of MS 2020 – Epidemiology Report (2020). MS International Federation. Available at: https://www.msif.org/resource/atlas-of-ms-2020/ (accessed March 28, 2023).
    1. Billinghurst L. L., Taylor R. M., Snyder E. Y. (1998). Remyelination: cellular and gene therapy. Semin. Pediatr. Neurol. 5, 211–228. doi: 10.1016/s1071-9091(98)80036-3 - DOI - PubMed
    1. Birmpili D., Charmarke Askar I., Bigaut K., Bagnard D. (2022). The translatability of multiple sclerosis animal models for biomarkers discovery and their clinical use. Int. J. Mol. Sci. 23:11532. doi: 10.3390/ijms231911532, PMID: - DOI - PMC - PubMed

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