Neonatal Cardiovascular Function after Antenatal Sildenafil for Severe, Early-Onset Intrauterine Growth Restriction: A Substudy of the STRIDER-NZAus Randomized Placebo-Controlled Trial

doi:10.1016/j.ympdx.2019.100009

Case Reports

. 2019 Nov 20:1:100009.

doi: 10.1016/j.ympdx.2019.100009. eCollection 2019 Spring.

Neonatal Cardiovascular Function after Antenatal Sildenafil for Severe, Early-Onset Intrauterine Growth Restriction: A Substudy of the STRIDER-NZAus Randomized Placebo-Controlled Trial

Sarah L Harris^{1

2}, Chris McKinlay³, Katie Groom^{3

4}, Friederike Beker^{5

6}, Anuradha Kochar⁷, Andrew Gill⁸

Affiliations

¹ University of Otago, Christchurch, New Zealand.
² Canterbury District Health Board, Christchurch, New Zealand.
³ University of Auckland, Auckland, New Zealand.
⁴ National Women's Health, Auckland City Hospital, Auckland, New Zealand.
⁵ Mater Research Institute, University of Queensland, South Brisbane, Queensland, Australia.
⁶ Neonatal Critical Care Unit, Mater Mothers Hospital, South Brisbane, Queensland, Australia.
⁷ Women's and Children's Hospital, Adelaide, Australia.
⁸ Center of Neonatal Research and Education, University of Western Australia, Perth, Australia.

PMID: 37333836
PMCID: PMC10236542
DOI: 10.1016/j.ympdx.2019.100009

Case Reports

Neonatal Cardiovascular Function after Antenatal Sildenafil for Severe, Early-Onset Intrauterine Growth Restriction: A Substudy of the STRIDER-NZAus Randomized Placebo-Controlled Trial

Sarah L Harris et al. J Pediatr X. 2019.

. 2019 Nov 20:1:100009.

doi: 10.1016/j.ympdx.2019.100009. eCollection 2019 Spring.

Authors

Sarah L Harris^{1

2}, Chris McKinlay³, Katie Groom^{3

4}, Friederike Beker^{5

6}, Anuradha Kochar⁷, Andrew Gill⁸

Affiliations

¹ University of Otago, Christchurch, New Zealand.
² Canterbury District Health Board, Christchurch, New Zealand.
³ University of Auckland, Auckland, New Zealand.
⁴ National Women's Health, Auckland City Hospital, Auckland, New Zealand.
⁵ Mater Research Institute, University of Queensland, South Brisbane, Queensland, Australia.
⁶ Neonatal Critical Care Unit, Mater Mothers Hospital, South Brisbane, Queensland, Australia.
⁷ Women's and Children's Hospital, Adelaide, Australia.
⁸ Center of Neonatal Research and Education, University of Western Australia, Perth, Australia.

PMID: 37333836
PMCID: PMC10236542
DOI: 10.1016/j.ympdx.2019.100009

Abstract

We evaluated the effect of antenatal sildenafil on neonatal cardiovascular function in a subgroup of 27 infants of mothers participating in the STRIDER-NZAus randomized controlled trial. In this small study, we found no association between antenatal sildenafil and neonatal cardiac dysfunction including no pulmonary hypertension in exposed or unexposed infants.

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Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations.
De Bie FR, Basurto D, Kumar S, Deprest J, Russo FM. De Bie FR, et al. Int J Environ Res Public Health. 2022 Sep 6;19(18):11207. doi: 10.3390/ijerph191811207. Int J Environ Res Public Health. 2022. PMID: 36141480 Free PMC article. Review.
Childhood outcomes after maternal antenatal sildenafil treatment for severe early-onset fetal growth restriction: a randomized trial (STRIDER NZAus).
McKinlay CJD, Anderson C, Cheong JLY, Gordon A, Harris SL, Hurrion EM, Ireland S, Koorts P, Lui K, Mackay L, Oakes-Ter Bals M, Opie G, Sharp M, Groom KM. McKinlay CJD, et al. J Perinatol. 2024 Mar;44(3):396-403. doi: 10.1038/s41372-023-01838-7. Epub 2023 Dec 6. J Perinatol. 2024. PMID: 38057497 Clinical Trial.
Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy.
Pels A, Ganzevoort W, Kenny LC, Baker PN, von Dadelszen P, Gluud C, Kariya CT, Leemhuis AG, Groom KM, Sharp AN, Magee LA, Jakobsen JC, Mol BWJ, Papageorghiou AT. Pels A, et al. Cochrane Database Syst Rev. 2023 Jul 10;7(7):CD014498. doi: 10.1002/14651858.CD014498. Cochrane Database Syst Rev. 2023. PMID: 37428872 Free PMC article.

References

1. Paauw N.D., Terstappen F., Ganzevoort W., Joles J.A., Gremmels H., Lely A.T. Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure. Hypertension. 2017;70:998–1006. - PubMed
1. von Dadelszen P., Dwinnell S., Magee L.A., Carleton B.C., Gruslin A., Lee B., et al. Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. BJOG. 2011;118:624–628. - PubMed
1. Pels A., Kenny L.C., Alfirevic Z., Baker P.N., von Dadelszen P., Gluud C., et al. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials. BMC Preg Childbirth. 2017;17:440. - PMC - PubMed
1. Groom K.M., McCowan L.M., Mackay L.K., Lee A.C., Gardener G., Unterscheider J., et al. STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction. BJOG. 2019;126:997–1006. - PubMed
1. Sharp A., Cornforth C., Jackson R., Harrold J., Turner M.A., Kenny L.C., et al. Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial. Lancet Child Adolesc Health. 2018;2:93–102. - PubMed

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[1] Paauw N.D., Terstappen F., Ganzevoort W., Joles J.A., Gremmels H., Lely A.T. Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure. Hypertension. 2017;70:998–1006. - PubMed

[2] Paauw N.D., Terstappen F., Ganzevoort W., Joles J.A., Gremmels H., Lely A.T. Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure. Hypertension. 2017;70:998–1006. - PubMed

[3] von Dadelszen P., Dwinnell S., Magee L.A., Carleton B.C., Gruslin A., Lee B., et al. Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. BJOG. 2011;118:624–628. - PubMed

[4] von Dadelszen P., Dwinnell S., Magee L.A., Carleton B.C., Gruslin A., Lee B., et al. Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. BJOG. 2011;118:624–628. - PubMed

[5] Pels A., Kenny L.C., Alfirevic Z., Baker P.N., von Dadelszen P., Gluud C., et al. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials. BMC Preg Childbirth. 2017;17:440. - PMC - PubMed

[6] Pels A., Kenny L.C., Alfirevic Z., Baker P.N., von Dadelszen P., Gluud C., et al. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials. BMC Preg Childbirth. 2017;17:440. - PMC - PubMed

[7] Groom K.M., McCowan L.M., Mackay L.K., Lee A.C., Gardener G., Unterscheider J., et al. STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction. BJOG. 2019;126:997–1006. - PubMed

[8] Groom K.M., McCowan L.M., Mackay L.K., Lee A.C., Gardener G., Unterscheider J., et al. STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction. BJOG. 2019;126:997–1006. - PubMed

[9] Sharp A., Cornforth C., Jackson R., Harrold J., Turner M.A., Kenny L.C., et al. Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial. Lancet Child Adolesc Health. 2018;2:93–102. - PubMed

[10] Sharp A., Cornforth C., Jackson R., Harrold J., Turner M.A., Kenny L.C., et al. Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial. Lancet Child Adolesc Health. 2018;2:93–102. - PubMed

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Neonatal Cardiovascular Function after Antenatal Sildenafil for Severe, Early-Onset Intrauterine Growth Restriction: A Substudy of the STRIDER-NZAus Randomized Placebo-Controlled Trial

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Neonatal Cardiovascular Function after Antenatal Sildenafil for Severe, Early-Onset Intrauterine Growth Restriction: A Substudy of the STRIDER-NZAus Randomized Placebo-Controlled Trial

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