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Review
. 2023 Jun 2:13:1191126.
doi: 10.3389/fcimb.2023.1191126. eCollection 2023.

Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications

Christina Tsigalou  1 , Afroditi Paraschaki  2 , Nicola Luigi Bragazzi  3 , K Aftzoglou  4 , Eugenia Bezirtzoglou  5 , Z Tsakris  6 , S Vradelis  7 , Elisavet Stavropoulou  8
Affiliations
Review

Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications

Christina Tsigalou et al. Front Cell Infect Microbiol. .

Erratum in

Abstract

Intestinal microorganisms play a crucial role in shaping the host immunity and maintaining homeostasis. Nevertheless, alterations in gut bacterial composition may occur and these alterations have been linked with the pathogenesis of several diseases. In surgical practice, studies revealed that the microbiome of patients undergoing surgery changes and several post-operative complications seem to be associated with the gut microbiota composition. In this review, we aim to provide an overview of gut microbiota (GM) in surgical disease. We refer to several studies which describe alterations of GM in patients undergoing different types of surgery, we focus on the impacts of peri-operative interventions on GM and the role of GM in development of post-operative complications, such as anastomotic leak. The review aims to enhance comprehension regarding the correlation between GM and surgical procedures based in the current knowledge. However, preoperative and postoperative synthesis of GM needs to be further examined in future studies, so that GM-targeted measures could be assessed and the different surgery complications could be reduced.

Keywords: alterations in microbiota; gut microbiota; microbiome; peri-operative interventions; surgery complications; surgical disease.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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