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. 2023 Sep;78(9):2497-2509.
doi: 10.1111/all.15783. Epub 2023 Jun 19.

A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity

E J J Kallen  1 , A Revers  2 , M Fernández-Rivas  3 , R Asero  4 , B Ballmer-Weber  5   6   7 , L Barreales  3 , S Belohlavkova  8 , F de Blay  9 , M Clausen  10 , R Dubakiene  11 , M Ebisawa  12 , C Fernández-Perez  13 , P Fritsche  5 , Y Fukutomi  12 , D Gislason  10 , K Hoffmann-Sommergruber  14 , M Jedrzejczak-Czechowicz  15 , A C Knulst  1 , M L Kowalski  15 , T Kralimarkova  16 , J Lidholm  17 , C Metzler  5 , E N C Mills  18 , N G Papadopoulos  19 , T A Popov  16 , A Purohit  9 , I Reig  20 , S L Seneviratne  21 , A Sinaniotis  19 , M Takei  12 , S A Versteeg  22 , A E Vassilopoulou  23 , S Vieths  24 , P M J Welsing  1 , A H Zwinderman  2 , T M Le  1 , R Van Ree  25
Affiliations

A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity

E J J Kallen et al. Allergy. 2023 Sep.

Abstract

Background: Pru p 3 and Pru p 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns to five peach components across Europe and in Japan, to explore their relation to pollen and foods and to predict symptom severity.

Methods: In twelve European (EuroPrevall project) and one Japanese outpatient clinic, a standardized clinical evaluation was conducted in 1231 patients who reported symptoms to peach and/or were sensitized to peach. Specific IgE against Pru p 1, 2, 3, 4 and 7 and against Cup s 7 was measured in 474 of them. Univariable and multivariable Lasso regression was applied to identify combinations of parameters predicting severity.

Results: Sensitization to Pru p 3 dominated in Southern Europe but was also quite common in Northern and Central Europe. Sensitization to Pru p 7 was low and variable in the European centers but very dominant in Japan. Severity could be predicted by a model combining age of onset of peach allergy, probable mugwort, Parietaria pollen and latex allergy, and sensitization to Japanese cedar pollen, Pru p 4 and Pru p 7 which resulted in an AUC of 0.73 (95% CI 0.73-0.74). Pru p 3 tended to be a risk factor in South Europe only.

Conclusions: Pru p 7 was confirmed as a significant risk factor for severe peach allergy in Europe and Japan. Combining outcomes from clinical and demographic background with serology resulted in a model that could better predict severity than CRD alone.

Keywords: Peach allergy; Pru p 3; Pru p 7; prediction; severity.

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References

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