Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug;238(8):1732-1755.
doi: 10.1002/jcp.31060. Epub 2023 Jun 19.

The origin, progress, and application of cell-based cardiac regeneration therapy

Danping Zhuo  1   2 , Ienglam Lei  3 , Wenjun Li  1   2 , Li Liu  1   2 , Lan Li  2 , Jingyu Ni  1 , Zhihao Liu  2 , Guanwei Fan  1   2
Affiliations
Review

The origin, progress, and application of cell-based cardiac regeneration therapy

Danping Zhuo et al. J Cell Physiol. 2023 Aug.

Abstract

Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity and mortality increasing yearly and gradually becoming younger. When the disease progresses to the middle and late stages, the loss of a large number of cardiomyocytes is irreparable to the body itself, and clinical drug therapy and mechanical support therapy cannot reverse the development of the disease. To explore the source of regenerated myocardium in model animals with the ability of heart regeneration through lineage tracing and other methods, and develop a new alternative therapy for CVDs, namely cell therapy. It directly compensates for cardiomyocyte proliferation through adult stem cell differentiation or cell reprogramming, which indirectly promotes cardiomyocyte proliferation through non-cardiomyocyte paracrine, to play a role in heart repair and regeneration. This review comprehensively summarizes the origin of newly generated cardiomyocytes, the research progress of cardiac regeneration based on cell therapy, the opportunity and development of cardiac regeneration in the context of bioengineering, and the clinical application of cell therapy in ischemic diseases.

Keywords: cardiac regeneration; cardiomyocyte proliferation; cardiovascular disease; cell therapy.

PubMed Disclaimer

References

REFERENCES

    1. Adler, C., & Friedburg, H. (1986). Myocardial DNA content, ploidy level and cell number in geriatric hearts: Post-mortem examinations of human myocardium in old age. Journal of Molecular and Cellular Cardiology, 18(1), 39-53. https://doi.org/10.1016/s0022-2828(86)80981-6
    1. Adler, C. P. (1976). DNS in Kinderherzen. Biochemische und zytophotometrische Untersuchungen. Beiträge zur Pathologie, 158(2), 173-202.
    1. Akerberg, B. N., Gu, F., Vandusen, N. J., Zhang, X., Dong, R., Li, K., Zhang, B., Zhou, B., Sethi, I., Ma, Q., Wasson, L., Wen, T., Liu, J., Dong, K., Conlon, F. L., Zhou, J., Yuan, G. C., Zhou, P., & Pu, W. T. (2019). A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nature Communications, 10(1), 4907. https://doi.org/10.1038/s41467-019-12812-3
    1. Alkass, K., Panula, J., Westman, M., Wu, T. D., Guerquin-Kern, J. L., & Bergmann, O. (2015). No evidence for cardiomyocyte number expansion in preadolescent mice. Cell, 163(4), 1026-1036. https://doi.org/10.1016/j.cell.2015.10.035
    1. Aurora, A. B., Porrello, E. R., Tan, W., Mahmoud, A. I., Hill, J. A., Bassel-Duby, R., Sadek, H. A., & Olson, E. N. (2014). Macrophages are required for neonatal heart regeneration. Journal of Clinical Investigation, 124(3), 1382-1392. https://doi.org/10.1172/JCI72181

Publication types

LinkOut - more resources