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. 2024 Jan;59(1):311-322.
doi: 10.1002/jmri.28869. Epub 2023 Jun 19.

Efficiency and Accuracy Evaluation of Multiple Diffusion-Weighted MRI Techniques Across Different Scanners

Frederik Crop  1   2 , Clémence Robert  1 , Romain Viard  3   4 , Julien Dumont  3 , Marine Kawalko  5 , Pauline Makala  6 , Xavier Liem  6 , Imen El Aoud  5 , Aicha Ben Miled  5 , Victor Chaton  5 , Lucas Patin  5 , David Pasquier  6   7 , Ophélie Guillaud  5 , Benjamin Vandendorpe  6 , Xavier Mirabel  6 , Luc Ceugnart  5 , Camille Decoene  1 , Thomas Lacornerie  1
Affiliations

Efficiency and Accuracy Evaluation of Multiple Diffusion-Weighted MRI Techniques Across Different Scanners

Frederik Crop et al. J Magn Reson Imaging. 2024 Jan.

Abstract

Background: The choice between different diffusion-weighted imaging (DWI) techniques is difficult as each comes with tradeoffs for efficient clinical routine imaging and apparent diffusion coefficient (ADC) accuracy.

Purpose: To quantify signal-to-noise-ratio (SNR) efficiency, ADC accuracy, artifacts, and distortions for different DWI acquisition techniques, coils, and scanners.

Study type: Phantom, in vivo intraindividual biomarker accuracy between DWI techniques and independent ratings.

Population/phantoms: NIST diffusion phantom. 51 Patients: 40 with prostate cancer and 11 with head-and-neck cancer at 1.5 T FIELD STRENGTH/SEQUENCE: Echo planar imaging (EPI): 1.5 T and 3 T Siemens; 3 T Philips. Distortion-reducing: RESOLVE (1.5 and 3 T Siemens); Turbo Spin Echo (TSE)-SPLICE (3 T Philips). Small field-of-view (FOV): ZoomitPro (1.5 T Siemens); IRIS (3 T Philips). Head-and-neck and flexible coils.

Assessment: SNR Efficiency, geometrical distortions, and susceptibility artifacts were quantified for different b-values in a phantom. ADC accuracy/agreement was quantified in phantom and for 51 patients. In vivo image quality was independently rated by four experts.

Statistical tests: QIBA methodology for accuracy: trueness, repeatability, reproducibility, Bland-Altman 95% Limits-of-Agreement (LOA) for ADC. Wilcoxon Signed-Rank and student tests on P < 0.05 level.

Results: The ZoomitPro small FOV sequence improved b-image efficiency by 8%-14%, reduced artifacts and observer scoring for most raters at the cost of smaller FOV compared to EPI. The TSE-SPLICE technique reduced artifacts almost completely at a 24% efficiency cost compared to EPI for b-values ≤500 sec/mm2 . Phantom ADC 95% LOA trueness were within ±0.03 × 10-3 mm2 /sec except for small FOV IRIS. The in vivo ADC agreement between techniques, however, resulted in 95% LOAs in the order of ±0.3 × 10-3 mm2 /sec with up to 0.2 × 10-3 mm2 /sec of bias.

Data conclusion: ZoomitPro for Siemens and TSE SPLICE for Philips resulted in a trade-off between efficiency and artifacts. Phantom ADC quality control largely underestimated in vivo accuracy: significant ADC bias and variability was found between techniques in vivo.

Level of evidence: 3 TECHNICAL EFFICACY STAGE: 2.

Keywords: accuracy; apparent diffusion coefficient; diffusion weighted imaging; efficiency; quantitative imaging biomarker; signal-to-noise ratio.

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References

    1. Luzurier A, Jouve De Guibert PH, Allera A, et al. Dynamic contrast-enhanced imaging in localizing local recurrence of prostate cancer after radiotherapy: Limited added value for readers of varying level of experience. J Magn Reson Imaging 2018;48:1012-1023.
    1. Vargas HA, Hötker AM, Goldman DA, et al. Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: Critical evaluation using whole-mount pathology as standard of reference. Eur Radiol 2016;26:1606-1612.
    1. Lotte R, Lafourcade A, Mozer P, et al. Multiparametric MRI for suspected recurrent prostate cancer after HIFU:Is DCE still needed? Eur Radiol 2018;28:3760-3769.
    1. Onal C, Erbay G, Guler OC, Oymak E. The prognostic value of mean apparent diffusion coefficient measured with diffusion-weighted magnetic resonance image in patients with prostate cancer treated with definitive radiotherapy. Radiother Oncol 2022;173:285-291.
    1. Alexander EJ, Murray JR, Morgan VA, et al. Validation of T2- and diffusion-weighted magnetic resonance imaging for mapping intra-prostatic tumour prior to focal boost dose-escalation using intensity-modulated radiotherapy (IMRT). Radiother Oncol 2019;141:181-187.

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