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. 2023 Oct;58(10):1573-1580.
doi: 10.1007/s00127-023-02513-0. Epub 2023 Jun 19.

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study

Lucia Sideli  1   2   3 , Monica Aas  4   5   6   7 , Diego Quattrone  5 , Daniele La Barbera  8 , Caterina La Cascia  8 , Laura Ferraro  8 , Luis Alameda  4   9   10   11 , Eva Velthorst  12 , Giulia Trotta  4 , Giada Tripoli  4   8   13 , Adriano Schimmenti  14 , Andrea Fontana  15 , Charlotte Gayer-Anderson  16   17 , Simona Stilo  4   18 , Fabio Seminerio  8 , Crocettarachele Sartorio  8 , Giovanna Marrazzo  8 , Antonio Lasalvia  19 , Sarah Tosato  19 , Ilaria Tarricone  20 , Domenico Berardi  21 , Giuseppe D'Andrea  21 ; EU-GEI WP2 Group; Celso Arango  22 , Manuel Arrojo  23 , Miguel Bernardo  24   25 , Julio Bobes  26 , Julio Sanjuán  27 , Jose Luis Santos  28 , Paulo Rossi Menezes  29 , Cristina Marta Del-Ben  30 , Hannah E Jongsma  31   32 , Peter B Jones  33   34 , James B Kirkbride  31 , Pierre-Michel Llorca  34 , Andrea Tortelli  35 , Baptiste Pignon  36   37   38 , Lieuwe de Haan  39 , Jean-Paul Selten  40   41 , Jim Van Os  4   41   42 , Bart P Rutten  41 , Richard Bentall  43 , Marta Di Forti  5 , Robin M Murray  4 , Craig Morgan #  16   17 , Helen L Fisher #  5   17
Collaborators, Affiliations

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study

Lucia Sideli et al. Soc Psychiatry Psychiatr Epidemiol. 2023 Oct.

Abstract

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Keywords: Childhood adversity; Cognition; Family history of psychosis; First episode; Polygenic risk score; Psychosis.

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Conflict of interest statement

Prof. Morgan is the Editor-in-Chief of this journal. Dr. Arango has been a consultant to or has received honoraria or grants from Acadia, Angelini, Boehringer, Gedeon Richter, Janssen Cilag, Lundbeck, Minerva, Otsuka, Pfizer, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda. Dr. Bernardo has been a consultant for, received grant/research support and honoraria from, and been on the speakers/advisory board of ABBiotics, Adamed, Angelini, Casen Recordati, Janssen-Cilag, Menarini, Rovi and Takeda. The other authors have declared that there are no conflicts of interest in relation to the subject of this study.

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