Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2023 Jun 19;38(1):142.
doi: 10.1007/s10103-023-03807-0.

Clinical and radiographic outcomes of adjunctive photodynamic therapy for treating peri-implantitis among diabetics and cigarette smokers: a systematic review of randomized controlled trials

Mohammad Khursheed Alam  1 , Abdullah Ali Alqahtani  2 , Mahmud Uz Zaman  3 , Bushra Kanwal  4 , Ali Robaian  2 , Fahda Alqahtani  5
Affiliations
Meta-Analysis

Clinical and radiographic outcomes of adjunctive photodynamic therapy for treating peri-implantitis among diabetics and cigarette smokers: a systematic review of randomized controlled trials

Mohammad Khursheed Alam et al. Lasers Med Sci. .

Abstract

Photodynamic therapy (PDT) has been suggested as an adjunctive therapeutic approach for peri-implantitis. This systematic review aimed to assess the clinical and radiographic outcomes of adjunctive PDT (aPDT) for the treatment of peri-implantitis among diabetics and cigarette smokers. Randomized controlled trials (RCTs), which assessed the clinical and radiographic outcomes of aPDT versus other intervention(s) and/or MD alone among diabetics and smokers with peri-implantitis, were considered eligible for the review. Meta-analysis was performed for calculating the standard mean difference (SMD) with a 95% confidence interval (CI). The methodological quality of the included studies was evaluated using the modified Jadad quality scale. The meta-analysis revealed no significant differences between the influence of aPDT and other intervention/MD alone on the peri-implant PI among diabetics at the final follow-up. However, statistically significant improvements in the peri-implant PD, BOP, and CBL were observed after the application of aPDT among diabetics. Similarly, no significant differences were found between the influence of aPDT and other interventions/MD alone on the peri-implant PD among smokers with peri-implant diseases at the final follow-up. However, statistically significant improvements in the peri-implant PI, BOP, and CBL were observed after the application of aPDT among smokers. Significant improvements in the peri-implant PD, BOP, and CBL among diabetics and the peri-implant PI, BOP, and CBL among smokers after the application of aPDT at the final follow-up. However, large-scale, well-designed, and long-term RCTs are recommended in this domain.

Keywords: Cigarette smoking; Diabetes Mellitus; Peri-implant mucositis; Peri-implantitis; Photochemotherapy.

PubMed Disclaimer

References

    1. Romanos GE, Javed F, Delgado-Ruiz RA, Calvo-Guirado JL (2015) Peri-implant diseases: a review of treatment interventions. Dent Clin 59:157–178
    1. Vohra F, Al-Rifaiy MQ, Lillywhite G, Abu Hassan MI, Javed F (2014) Efficacy of mechanical debridement with adjunct antimicrobial photodynamic therapy for the management of peri-implant diseases: a systematic review. Photochem Photobiol Sci 13:1160–1168 - PubMed
    1. Zitzmann NU, Berglundh T (2008) Definition and prevalence of peri-implant diseases. J Clin Periodontol 35:286–291 - PubMed
    1. Lindhe J, Meyle J, Group D of the European Workshop on Periodontology (2008) Peri-implant diseases: consensus report of the sixth European workshop on periodontology. J Clin Periodontol 35:282–285 - PubMed
    1. ALHarthiAlamryBinShabaib SSNZMS (2022) Effect of multiple sessions of photodynamic therapy on bone regeneration around dental implants among patients with peri-implantitis. Photodiagn Photodyn Ther 37:102612

LinkOut - more resources