doi: 10.1007/BF02590747.
In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide
- PMID: 373354
- DOI: 10.1007/BF02590747
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In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide
Acta Diabetol Lat.
1978 Sep-Dec.
Abstract
Cathepsin B, purified from isolated islets of Langerhans, when incubated with proinsulin under in vitro conditions could convert proinsulin to insulin and C-peptide, releasing free arginine and lysine. When C-peptide, prepared from rat pancreas, was added to the incubation system consisting of proinsulin and cathepsin B, it completely inhibited the conversion of proinsulin to insulin.
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