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. 1978 Sep-Dec;15(5-6):243-50.
doi: 10.1007/BF02590747.

In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide

R B Puri, K Anjaneyulu, J R Kidwai, V K Mohan Rao

In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide

R B Puri et al. Acta Diabetol Lat. 1978 Sep-Dec.

Abstract

Cathepsin B, purified from isolated islets of Langerhans, when incubated with proinsulin under in vitro conditions could convert proinsulin to insulin and C-peptide, releasing free arginine and lysine. When C-peptide, prepared from rat pancreas, was added to the incubation system consisting of proinsulin and cathepsin B, it completely inhibited the conversion of proinsulin to insulin.

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