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Comment
. 2023 Nov;33(11):819-820.
doi: 10.1038/s41422-023-00838-8.

GPCRs and β-arrestins - an on-off relationship

Alex R B Thomsen  1   2
Affiliations
Comment

GPCRs and β-arrestins - an on-off relationship

Alex R B Thomsen. Cell Res. 2023 Nov.
No abstract available

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Figures

Fig. 1
Fig. 1. A cytosolic view of how a membrane-embedded βarr2 diffuses freely and encounters an agonist-stimulated GPCR to form a transient complex.
This short-lived association activates βarr2, which diffuses toward a CCP independently of the GPCR.
See this image and copyright information in PMC

Comment on

  • Plasma membrane preassociation drives β-arrestin coupling to receptors and activation.
    Grimes J, Koszegi Z, Lanoiselée Y, Miljus T, O'Brien SL, Stepniewski TM, Medel-Lacruz B, Baidya M, Makarova M, Mistry R, Goulding J, Drube J, Hoffmann C, Owen DM, Shukla AK, Selent J, Hill SJ, Calebiro D. Grimes J, et al. Cell. 2023 May 11;186(10):2238-2255.e20. doi: 10.1016/j.cell.2023.04.018. Epub 2023 May 4. Cell. 2023. PMID: 37146613 Free PMC article.

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