Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Nana Liu^#¹, Longjiang Zhang^#², Tian Tian^#³, Jingliang Cheng⁴, Bing Zhang⁵, Shijun Qiu⁶, Zuojun Geng⁷, Guangbin Cui⁸, Quan Zhang⁹, Weihua Liao^{10

11

12}, Yongqiang Yu¹³, Hui Zhang¹⁴, Bo Gao^{15

16}, Xiaojun Xu¹⁷, Tong Han¹⁸, Zhenwei Yao¹⁹, Wen Qin¹, Feng Liu¹, Meng Liang²⁰, Qiang Xu¹, Jilian Fu¹, Jiayuan Xu¹, Wenzhen Zhu³, Peng Zhang²¹, Wei Li²¹, Dapeng Shi²², Caihong Wang⁴, Su Lui²³, Zhihan Yan²⁴, Feng Chen²⁵, Jiance Li²⁶, Jing Zhang^{27

28}, Dawei Wang²⁹, Wen Shen³⁰, Yanwei Miao³¹, Junfang Xian³², Jia-Hong Gao³³, Xiaochu Zhang³⁴, Mulin Jun Li³⁵, Kai Xu³⁶, Xi-Nian Zuo^{37

38}, Meiyun Wang³⁹, Zhaoxiang Ye⁴⁰, Chunshui Yu^{41

42}; CHIMGEN Consortium

Collaborators, Affiliations

Collaborators

CHIMGEN Consortium:
Quan Zhang, Junping Wang, Xue Zhang, Xinjun Suo, Congcong Yuan, Yuan Ji, Hui Xue, Tianying Gao, Junpeng Liu, Yanjun Li, Xi Guo, Lixue Xu, Jiajia Zhu, Huaigui Liu, Fangshi Zhao, Jie Sun, Yongjie Xu, Huanhuan Cai, Jie Tang, Yaodan Zhang, Yongqin Xiong, Xianting Sun, Nannan Pan, Xue Zhang Jr, Jiayang Yang, Ya Wen, Dan Zhu, Bingjie Wu, Wenshuang Zhu, Qingqing Diao, Yujuan Cao, Bingbing Yang, Lining Guo, Yingying Xie, Jiahui Lin, Zhimin Li, Yan Zhang, Kaizhong Xue, Zirui Wang, Junlin Shen, Xuejun Zhang, Hao Ding, Qian Su, Shijie Zhang, Lun Ma, Yan Bai, Min Guan, Wei Wei, Peifang Miao, Fuhong Duan, Yafei Guo, Weijian Wang, Lijuan Zheng, Li Lin, Yunfei Wang, Han Zhang, Xinyuan Zhang, Zhao Qing, Sichu Wu, Junxia Wang, Yi Sun, Yang He, Zhe Zhang, Yin-Shan Wang, Quan Zhou, Yi Liang, Yujie Liu, Hui Zeng, Jingxian Chen, Haitao Ge, Peng Xu, Cailuan Lu, Chen Wu, Xiaoying Yang, Yuzhao Wang, Yankai Wu, Xuran Feng, Ling Li, Duo Gao, Rujing Zha, Ying Li, Lizhuang Yang, Ying Chen, Ling Zuo, Jianqiao Ge, Guoyuan Yang, Wen Wang, Linfeng Yan, Yang Yang, Jin Zhang, Qian Wang, Xiaoxia Qu, Ying Wang, Fei Yuan, Li Hu, Jizhen Li, Weiwei Wang, Yujing Zhou, Miaomiao Long, Lihua Liu, Xiaohu Li, Xiaoshu Li, Yunjun Yang, Nengzhi Xia, Shuai Yang, Youming Zhang, Guangyao Liu, Laiyang Ma, Xiaochun Wang, Ying Lei, Gang Zhang, Kang Yuan, Jingjing Xu, Xiaojun Guan, Yuankai Lin, Huijuan Chen, Yuchuan Fu, Yi Lu, Jun Guo, Hao Lu, Yue Wu

Affiliations

¹ Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
² Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
³ Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
⁶ Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
⁷ Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
⁸ Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
⁹ Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China.
¹⁰ Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
¹¹ Molecular Imaging Research Center of Central South University, Changsha, China.
¹² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
¹³ Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
¹⁴ Department of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China.
¹⁵ Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
¹⁶ Department of Radiology, Yantai Yuhuangding Hospital, Yantai, China.
¹⁷ Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
¹⁸ Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China.
¹⁹ Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
²⁰ School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China.
²¹ Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
²² Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.
²³ Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
²⁴ Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
²⁵ Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.
²⁶ Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
²⁷ Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China.
²⁸ Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China.
²⁹ Department of Radiology, Qilu Hospital of Shandong University, Jinan, China.
³⁰ Department of Radiology, Tianjin First Center Hospital, Tianjin, China.
³¹ Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
³² Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
³³ Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
³⁴ Division of Life Science and Medicine, University of Science & Technology of China, Hefei, China.
³⁵ Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
³⁶ Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
³⁷ Developmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
³⁸ Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
³⁹ Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China. mywang@ha.edu.cn.
⁴⁰ Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. yezhaoxiang@163.com.
⁴¹ Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China. chunshuiyu@tmu.edu.cn.
⁴² CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. chunshuiyu@tmu.edu.cn.

^# Contributed equally.

PMID: 37337106
DOI: 10.1038/s41588-023-01425-8

Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Nana Liu et al. Nat Genet. 2023 Jul.

. 2023 Jul;55(7):1126-1137.

doi: 10.1038/s41588-023-01425-8. Epub 2023 Jun 19.

Authors

Collaborators

CHIMGEN Consortium:
Quan Zhang, Junping Wang, Xue Zhang, Xinjun Suo, Congcong Yuan, Yuan Ji, Hui Xue, Tianying Gao, Junpeng Liu, Yanjun Li, Xi Guo, Lixue Xu, Jiajia Zhu, Huaigui Liu, Fangshi Zhao, Jie Sun, Yongjie Xu, Huanhuan Cai, Jie Tang, Yaodan Zhang, Yongqin Xiong, Xianting Sun, Nannan Pan, Xue Zhang Jr, Jiayang Yang, Ya Wen, Dan Zhu, Bingjie Wu, Wenshuang Zhu, Qingqing Diao, Yujuan Cao, Bingbing Yang, Lining Guo, Yingying Xie, Jiahui Lin, Zhimin Li, Yan Zhang, Kaizhong Xue, Zirui Wang, Junlin Shen, Xuejun Zhang, Hao Ding, Qian Su, Shijie Zhang, Lun Ma, Yan Bai, Min Guan, Wei Wei, Peifang Miao, Fuhong Duan, Yafei Guo, Weijian Wang, Lijuan Zheng, Li Lin, Yunfei Wang, Han Zhang, Xinyuan Zhang, Zhao Qing, Sichu Wu, Junxia Wang, Yi Sun, Yang He, Zhe Zhang, Yin-Shan Wang, Quan Zhou, Yi Liang, Yujie Liu, Hui Zeng, Jingxian Chen, Haitao Ge, Peng Xu, Cailuan Lu, Chen Wu, Xiaoying Yang, Yuzhao Wang, Yankai Wu, Xuran Feng, Ling Li, Duo Gao, Rujing Zha, Ying Li, Lizhuang Yang, Ying Chen, Ling Zuo, Jianqiao Ge, Guoyuan Yang, Wen Wang, Linfeng Yan, Yang Yang, Jin Zhang, Qian Wang, Xiaoxia Qu, Ying Wang, Fei Yuan, Li Hu, Jizhen Li, Weiwei Wang, Yujing Zhou, Miaomiao Long, Lihua Liu, Xiaohu Li, Xiaoshu Li, Yunjun Yang, Nengzhi Xia, Shuai Yang, Youming Zhang, Guangyao Liu, Laiyang Ma, Xiaochun Wang, Ying Lei, Gang Zhang, Kang Yuan, Jingjing Xu, Xiaojun Guan, Yuankai Lin, Huijuan Chen, Yuchuan Fu, Yi Lu, Jun Guo, Hao Lu, Yue Wu

Affiliations

¹ Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
² Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
³ Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
⁶ Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
⁷ Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
⁸ Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
⁹ Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China.
¹⁰ Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
¹¹ Molecular Imaging Research Center of Central South University, Changsha, China.
¹² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
¹³ Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
¹⁴ Department of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China.
¹⁵ Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
¹⁶ Department of Radiology, Yantai Yuhuangding Hospital, Yantai, China.
¹⁷ Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
¹⁸ Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China.
¹⁹ Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
²⁰ School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China.
²¹ Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
²² Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.
²³ Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
²⁴ Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
²⁵ Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.
²⁶ Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
²⁷ Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China.
²⁸ Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China.
²⁹ Department of Radiology, Qilu Hospital of Shandong University, Jinan, China.
³⁰ Department of Radiology, Tianjin First Center Hospital, Tianjin, China.
³¹ Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
³² Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
³³ Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
³⁴ Division of Life Science and Medicine, University of Science & Technology of China, Hefei, China.
³⁵ Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
³⁶ Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
³⁷ Developmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
³⁸ Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
³⁹ Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China. mywang@ha.edu.cn.
⁴⁰ Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. yezhaoxiang@163.com.
⁴¹ Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China. chunshuiyu@tmu.edu.cn.
⁴² CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. chunshuiyu@tmu.edu.cn.

^# Contributed equally.

PMID: 37337106
DOI: 10.1038/s41588-023-01425-8

Abstract

The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function. Genome-wide association studies on hippocampal and subfield volumes are mainly conducted in European populations; however, other ancestral populations are under-represented. Here we conduct cross-ancestry genome-wide association meta-analyses in 65,791 individuals for hippocampal volume and 38,977 for subfield volumes, including 7,009 individuals of East Asian ancestry. We identify 339 variant-trait associations at P < 1.13 × 10^-9 for 44 hippocampal traits, including 23 new associations. Common genetic variants have similar effects on hippocampal traits across ancestries, although ancestry-specific associations exist. Cross-ancestry analysis improves the fine-mapping precision and the prediction performance of polygenic scores in under-represented populations. These genetic variants are enriched for Wnt signaling and neuron differentiation and affect cognition, emotion and neuropsychiatric disorders. These findings may provide insight into the genetic architectures of hippocampal and subfield volumes.

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References

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Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Collaborators

Affiliations

Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Authors

Collaborators

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Abstract

References

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Medical