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. 2023 Jun 19;12(1):27.
doi: 10.1186/s13741-023-00317-z.

Comparison of tramadol and lornoxicam for the prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial

Xin Liao  1 , Min Xie  1 , Shuying Li  2 , Xiaolan Yu  1
Affiliations

Comparison of tramadol and lornoxicam for the prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial

Xin Liao et al. Perioper Med (Lond). .

Abstract

Background: Catheter-related bladder discomfort (CRBD is a painful complication of intraoperative urinary catheterization after anaesthesia. We conducted this study to compare the effect of tramadol and lornoxicam for the prevention of postoperative CRBD.

Methods: One-hundred twenty patients (aged 18-60 years, ASA physical status 1-2, undergoing elective uterine surgery requiring intraoperative urinary catheterization were randomly divided into three groups with 40 patients in each group. Group T received 1.5 mg/kg tramadol, group L received 8-mg lornoxicam, and group C received normal saline. The study drugs were administered intravenously at the end of the surgery. The incidence and severity of CRBD were reported at 0, 1, 2, and 6 h after arrival at the postanaesthesia care unit (PACU).

Results: The incidence of CRBD was significantly lower in groups T and L than in group C at 1, 2, and 6 h after surgery. The incidence of moderate to severe CRBD was also significantly lower in groups T and L than in group C at 0, 1, and 2 h after surgery. The severity of CRBD reported as mild, moderate, and severe was reduced in groups T and L compared with group C at most times after surgery. Group T had a higher incidence of nausea than group C, and there were no differences in dizziness, drowsiness, or vomit among the three groups.

Conclusions: Tramadol and lornoxicam administered intravenously at the end of the surgery were both effective in preventing the incidence and severity of CRBD after uterine surgery. However, tramadol increased the incidence of nausea compared with saline, but there was no difference between tramadol and lornoxicam.

Trial registration: ChiCTR2100052003. Registered on 12/10/2021.

Keywords: Catheter-related bladder discomfort; Lornoxicam; Tramadol.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
CONSORT flow diagram
Fig. 2
Fig. 2
The incidence of CRBD among the three groups. *P < 0.05 for comparison between group T vs group C; **P < 0.05 for comparison between group L vs group C
Fig. 3
Fig. 3
The incidence of CRBD above mild among the three groups. *P < 0.05 for comparison between group T vs group C; **P < 0.05 for comparison between group L vs group C
Fig. 4
Fig. 4
Adverse effects among the three groups. *P < 0.05 for comparison between group T vs group C
See this image and copyright information in PMC

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References

    1. Agarwal A, Yadav G, Gupta D, Singh PK, Singh U. Evaluation of intra-operative tramadol for prevention of catheter-related bladder discomfort: a prospective, randomized, double-blind study. Br J Anaesth. 2008;101(4):506–510. doi: 10.1093/bja/aen217. - DOI - PubMed
    1. Andersson KE. The pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev. 1993;45(3):253–308. - PubMed
    1. Andersson KE. Detrusor myocyte activity and afferent signaling. Neurourol Urodyn. 2010;29(1):97–106. doi: 10.1002/nau.20784. - DOI - PubMed
    1. Andersson KE, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 2004;84(3):935–986. doi: 10.1152/physrev.00038.2003. - DOI - PubMed
    1. Aoki K, Hirayama A, Tanaka N, Yoneda T, Yoshida K, Fujimoto K, et al. A higher level of prostaglandin E2 in the urinary bladder in young boys and boys with lower urinary tract obstruction. Biomed Res. 2009;30(6):343–347. doi: 10.2220/biomedres.30.343. - DOI - PubMed

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