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Comment
. 2023 Oct;78(10):1306-1307.
doi: 10.1111/anae.16066. Epub 2023 Jun 19.

Carbetocin vs. oxytocin at elective caesarean delivery: challenges and complexities in performing and interpreting a non-inferiority trial

I P Hughes  1 , S Butler  1
Affiliations
Comment

Carbetocin vs. oxytocin at elective caesarean delivery: challenges and complexities in performing and interpreting a non-inferiority trial

I P Hughes et al. Anaesthesia. 2023 Oct.
No abstract available

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References

    1. McDonagh F, Carvalho JCA, Abdulla S, et al. Carbetocin vs. oxytocin at elective caesarean delivery: a double-blind, randomised, controlled, non-inferiority trial of low- and high-dose regimens. Anaesthesia 2022; 77: 892-900.
    1. Walker J. Non-inferiority statistics and equivalence studies. British Journal of Anaesthesia Education 2019; 19: 267-71.
    1. Cuzick J, Sasieni P. Interpreting the results of noninferiority trials-a review. British Journal of Cancer 2022; 127: 1755-9.
    1. Rosseland LA, Hauge TH, Grindheim G, Stubhaug A, Langesaeter E. Changes in blood pressure and cardiac output during cesarean delivery: the effects of oxytocin and carbetocin compared with placebo. Anesthesiology 2013; 119: 541-51.
    1. World Health Organization. WHO recommendations: Uterotonics for the prevention of postpartum haemorrhage. Web annex 2: Carbetocin versus placebo or no treatment. 2018. https://www.ncbi.nlm.nih.gov/books/NBK535977/pdf/Bookshelf_NBK535977.pdf (accessed 17/05/2023).

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