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. 1986;112(1):47-9.
doi: 10.1007/BF00394938.

Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC)

M C Bibby, J A Double

Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC)

M C Bibby et al. J Cancer Res Clin Oncol. 1986.

Abstract

The anti-neoplastic activity of N-[N'-(2-chloroethyl)-N-nitrosocarbamoyl(CNC)]-alanine, CNC-alanyl-alanine, CNC-alanine-methylamide and CNC-glycine-methylamide was examined in murine transplantable colon tumours (MAC). The methylamide derivatives were highly active against a solid adenocarcinoma (MAC 13) and an ascitic adenocarcinoma (MAC 15 A). CNC-alanyl-alanine was also highly active against MAC 15 A. Responses of the three latter agents against the ascitic tumour were better than for any previously tested drugs including the nitrosoureas but their eventual usefulness cannot be determined without further toxicological studies.

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References

    1. Ball CR, Double JA (1975) Transplantable adenocarcinomas of the colon in mice as possible models for chemotherapy. Br J Cancer 31:264 - PMC - PubMed
    1. Cowen DM, Double JA, Cowen PN (1980) Some biological characteristics of transplantable lines of mouse adenocarcinoma of the colon. J Natl Inst 64:675–681 - PubMed
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    1. Double JA, Ball CR, Cowen PN (1975) Transplantation of adenocarcinoma of the colon in mice. J Natl Cancer Inst 54:271–275 - PubMed

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