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Review
. 2023 Jul;13(7):1465-1475.
doi: 10.1007/s13555-023-00964-6. Epub 2023 Jun 20.

The Relationship Between Rosacea and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Yu Kyung Jun  1   2   3 , Da-Ae Yu  4 , Yoo Min Han  5   2 , Soo Ran Lee  6 , Seong-Joon Koh #  7   8 , Hyunsun Park #  9   10
Affiliations
Review

The Relationship Between Rosacea and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Yu Kyung Jun et al. Dermatol Ther (Heidelb). 2023 Jul.

Abstract

Introduction: Rosacea and inflammatory bowel disease (IBD) are chronic inflammatory disorders of the skin and the gut, which are interfaces between the environment and the human body. Although growing evidence has implicated a possible link between rosacea and IBD, it remains unclear whether IBD increases the risk of rosacea and vice versa. Therefore, we investigated the association between rosacea and IBD in this study.

Methods: We performed a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines.

Results: Eight eligible studies were included in this meta-analysis. Overall, the prevalence of rosacea was higher in the IBD group than in the control group, with a pooled odds ratio (OR) of 1.86 (95% confidence interval [CI](1), 1.52-2.26). Both the Crohn's disease and the ulcerative colitis groups had higher prevalences of rosacea than the control group, with ORs of 1.74 (95% CI 1.34-2.28) and 2.00 (95% CI 1.63-2.45), respectively. Compared with those in the control group, the risks of IBD, Crohn's disease, and ulcerative colitis were significantly higher in the rosacea group, with incidence rate ratios of 1.37 (95% CI 1.22-1.53), 1.60 (95% CI 1.33-1.92), and 1.26 (95% CI 1.09-1.45), respectively.

Conclusion: Our meta-analysis suggests that IBD is bidirectionally associated with rosacea. Future interdisciplinary studies are needed to better understand the mechanism of interaction between rosacea and IBD .

Keywords: Colitis; Crohn’s disease; Inflammatory bowel disease; Meta-analysis; Rosacea; Systematic review; Ulcerative.

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Conflict of interest statement

Yu Kyung Jun, Da-Ae Yu, Yoo Min Han, Soo Ran Lee, Seong-Joon Koh, and Hyunsun Park have nothing to disclose.

Figures

Fig. 1
Fig. 1
Flow diagram of study selection. n number; IBD inflammatory bowel disease
Fig. 2
Fig. 2
Patients with a inflammatory bowel disease, b Crohn’s disease, and c ulcerative colitis had a higher prevalence of concomitant rosacea compared to controls. IBD inflammatory bowel disease; M–H Mantel–Haenszel; CI confidence interval; df degrees of freedom; CD Crohn’s disease; UC ulcerative colitis
Fig. 3
Fig. 3
Relative risks of a inflammatory bowel disease, b Crohn’s disease, and c ulcerative colitis were significantly higher in the rosacea group than in the controls. IBD inflammatory bowel disease; SE standard error; CI confidence interval; df degrees of freedom; CD Crohn’s disease; UC ulcerative colitis
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